Detailed information of TA system TA164917

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4491650..4491908
• Replicon: chromosome
• Accession: NZ_CP057210
• Organism: Escherichia fergusonii strain RHB33-C07

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVZ09_RS21850
• Protein ID: WP_001135723.1
• Coordinates: 4491650..4491802 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4491853..4491908 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ09_RS21825	4487509..4488219	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVZ09_RS21830	4488657..4490033	+	1377	WP_181666939.1	MFS transporter	-
HVZ09_RS21835	4490283..4490573	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVZ09_RS21840	4490854..4491066	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVZ09_RS21845	4491120..4491491	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
HVZ09_RS21850	4491650..4491802	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4491853..4491908	+	56	-	-	Antitoxin
HVZ09_RS21855	4492125..4494194	-	2070	WP_001291792.1	glycine--tRNA ligase subunit beta	-
HVZ09_RS21860	4494204..4495115	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVZ09_RS21865	4495211..4495510	-	300	WP_181667494.1	YsaB family lipoprotein	-
HVZ09_RS21870	4495682..4496677	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T164917 WP_001135723.1 NZ_CP057210:c4491802-4491650 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T164917 NZ_CP073588:c3797802-3797512 [Shewanella vesiculosa]
GTGCACGTTATTTCAAGAAAACCATTTAATGATGCCGCCCAAAAGTATCCTAACGATAGGGACGCCTTGGTTCAAATATA
CAGCACCTTACGCAGTGGCACATTCACCAATCCTGATGATTTACGGCAAGTATTTCCGTCTTTGGATAACTTTAAATATC
GAGATAAATGGTGGGTGATTGATGTAGGTGGTAATAATCTACGCATTATAGCCTTCATCGAGTTCCGAGATAACAGGATG
TATGTGAAGCACGTGGTTAGCCATGCAGACTATAGTCGAACAAAGGAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT164917 NZ_CP057210:4491853-4491908 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin