Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2520073..2520635 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVZ46_RS11930 Protein ID WP_181619432.1
Coordinates 2520073..2520351 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVZ46_RS11935 Protein ID WP_096757032.1
Coordinates 2520351..2520635 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS11910 2515183..2515614 - 432 WP_096757037.1 OsmC family protein -
HVZ46_RS11915 2515843..2515983 + 141 WP_181619429.1 stationary-phase-induced ribosome-associated protein -
HVZ46_RS11920 2516163..2517860 + 1698 WP_181619430.1 malate dehydrogenase -
HVZ46_RS11925 2518170..2519885 + 1716 WP_181619431.1 ATP-binding cassette domain-containing protein -
HVZ46_RS11930 2520073..2520351 + 279 WP_181619432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ46_RS11935 2520351..2520635 + 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
HVZ46_RS11940 2520741..2521397 - 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
HVZ46_RS11945 2521390..2522274 - 885 WP_115258486.1 formate dehydrogenase N subunit beta -
HVZ46_RS11950 2522288..2525335 - 3048 WP_181616957.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10624.09 Da        Isoelectric Point: 9.5325

>T164842 WP_181619432.1 NZ_CP057136:2520073-2520351 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGIWSISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T164842 NZ_CP073354:1175-1489 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT164842 WP_096757032.1 NZ_CP057136:2520351-2520635 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT164842 NZ_CP073354:909-1187 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References