Detailed information of TA system TA164816

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4343886..4344143
• Replicon: chromosome
• Accession: NZ_CP057104
• Organism: Escherichia fergusonii strain RHB38-C01

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HVZ66_RS21045
• Protein ID: WP_001135731.1
• Coordinates: 4343886..4344038 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4344095..4344143 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ66_RS21020	4339752..4340462	-	711	WP_181590944.1	DUF3053 domain-containing protein	-
HVZ66_RS21025	4340900..4342270	+	1371	WP_181590945.1	MFS transporter	-
HVZ66_RS21030	4342520..4342810	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVZ66_RS21035	4343092..4343304	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVZ66_RS21040	4343358..4343729	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HVZ66_RS21045	4343886..4344038	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4344095..4344143	+	49	-	-	Antitoxin
HVZ66_RS21050	4344360..4346429	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVZ66_RS21055	4346439..4347350	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVZ66_RS21060	4347446..4347745	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVZ66_RS21065	4347917..4348912	+	996	WP_181590946.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T164816 WP_001135731.1 NZ_CP057104:c4344038-4343886 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T164816 NZ_CP073310:4962819-4963193 [Enterobacter cloacae]
GTGTGGACAATTAACACGACGGACAGGTTCGATTGCTGGTTTCGTTCACTTGACGATACTGATCGGGCCAGCGTGCTGGC
AGCACTGCTTGTTTTGCGAGAAAAGGGGCCTGCTTTGTCGAGGCCCTATGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTGCGCATTCAGAGTAAGAGCGATCCGTTGCGGGCATTTTTCGCGTTTGACCCAAACCGTACCGGCATT
GTGCTCTGTGCCGGCAATAAGGTCGGCAACGAAAGACGCTTTTACGATGAAATGCTTCTGGTGGCCGACCGGGAATTCAC
TCACTGGTTGAATACATTAAAAGAAAGGACGTTACGCGATGGGCAGAAACCTTGA

Antitoxin

Nucleotide

• Length: 49 bp

>AT164816 NZ_CP057104:4344095-4344143 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin