Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3615251..3615905 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVZ66_RS17565 Protein ID WP_000244781.1
Coordinates 3615251..3615658 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVZ66_RS17570 Protein ID WP_000354046.1
Coordinates 3615639..3615905 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS17545 3611208..3612941 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ66_RS17550 3612947..3613657 - 711 WP_181590784.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ66_RS17555 3613682..3614578 - 897 WP_181590785.1 site-specific tyrosine recombinase XerD -
HVZ66_RS17560 3614690..3615211 + 522 WP_001055874.1 flavodoxin FldB -
HVZ66_RS17565 3615251..3615658 - 408 WP_000244781.1 protein YgfX Toxin
HVZ66_RS17570 3615639..3615905 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVZ66_RS17575 3616157..3617137 + 981 WP_181590786.1 tRNA-modifying protein YgfZ -
HVZ66_RS17580 3617214..3617873 - 660 WP_000250283.1 hemolysin III family protein -
HVZ66_RS17585 3618037..3618348 - 312 WP_181590787.1 N(4)-acetylcytidine aminohydrolase -
HVZ66_RS17590 3618393..3619826 + 1434 WP_046083325.1 6-phospho-beta-glucosidase BglA -
HVZ66_RS17595 3619874..3620767 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T164805 WP_000244781.1 NZ_CP057104:c3615658-3615251 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164805 NZ_CP073303:124627-124776 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164805 WP_000354046.1 NZ_CP057104:c3615905-3615639 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164805 NZ_CP073303:c124582-124523 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References