Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1670354..1671188 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag HVZ66_RS08005 Protein ID WP_000854808.1
Coordinates 1670811..1671188 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag HVZ66_RS08000 Protein ID WP_001354276.1
Coordinates 1670354..1670722 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS07975 1667470..1668288 + 819 WP_001234702.1 DUF945 domain-containing protein -
HVZ66_RS07980 1668379..1668864 + 486 WP_000214317.1 antirestriction protein -
HVZ66_RS07985 1668879..1669355 + 477 WP_001384029.1 RadC family protein -
HVZ66_RS07990 1669424..1669645 + 222 WP_181591371.1 DUF987 domain-containing protein -
HVZ66_RS07995 1669660..1670304 + 645 WP_029396485.1 hypothetical protein -
HVZ66_RS08000 1670354..1670722 + 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HVZ66_RS08005 1670811..1671188 + 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
HVZ66_RS08010 1671185..1671673 + 489 WP_000761657.1 hypothetical protein -
HVZ66_RS08015 1671685..1671882 + 198 WP_000839248.1 DUF957 domain-containing protein -
HVZ66_RS08020 1671967..1672809 + 843 WP_181464978.1 DUF4942 domain-containing protein -
HVZ66_RS08030 1674190..1674408 - 219 WP_001040187.1 translation initiation factor IF-1 -
HVZ66_RS08035 1674693..1675397 - 705 WP_001241690.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T164792 WP_000854808.1 NZ_CP057104:1670811-1671188 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T164792 NZ_CP073286:c155383-154940 [Klebsiella pneumoniae subsp. ozaenae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT164792 WP_001354276.1 NZ_CP057104:1670354-1670722 [Escherichia fergusonii]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT164792 NZ_CP073286:c155610-155380 [Klebsiella pneumoniae subsp. ozaenae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References