Detailed information of TA system TA164788

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 910986..911232
• Replicon: chromosome
• Accession: NZ_CP057104
• Organism: Escherichia fergusonii strain RHB38-C01

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVZ66_RS04470
• Protein ID: WP_000956458.1
• Coordinates: 911080..911232 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	910986..911038 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ66_RS04455	906494..908293	+	1800	WP_181591181.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVZ66_RS04460	908293..910005	+	1713	WP_046083135.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVZ66_RS04465	910079..910813	+	735	WP_000039850.1	phosphoadenosine phosphosulfate reductase	-
-	910986..911038	-	53	-	-	Antitoxin
HVZ66_RS04470	911080..911232	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVZ66_RS04475	911450..912136	+	687	Protein_864	CRISPR-associated endonuclease Cas3''	-
HVZ66_RS04480	912155..913453	+	1299	Protein_865	CRISPR-associated helicase Cas3'	-
HVZ66_RS04485	914247..914765	+	519	WP_181591182.1	hypothetical protein	-
HVZ66_RS04490	914784..915206	+	423	WP_181591183.1	hypothetical protein	-
HVZ66_RS04495	915336..915887	+	552	WP_181591184.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T164788 WP_000956458.1 NZ_CP057104:911080-911232 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T164788 NZ_CP073285:c4923627-4923343 [Klebsiella pneumoniae subsp. ozaenae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT164788 NZ_CP057104:c911038-910986 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin