Detailed information of TA system TA164785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 608768..609026
• Replicon: chromosome
• Accession: NZ_CP057104
• Organism: Escherichia fergusonii strain RHB38-C01

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVZ66_RS03090
• Protein ID: WP_000935262.1
• Coordinates: 608768..608977 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	608969..609026 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ66_RS03070	603835..604422	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVZ66_RS03075	604456..605022	-	567	WP_000528529.1	acetate uptake transporter	-
HVZ66_RS03080	605529..607445	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVZ66_RS03085	607534..608664	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVZ66_RS03090	608768..608977	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	608969..609026	+	58	-	-	Antitoxin
HVZ66_RS03095	609461..610627	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVZ66_RS03100	610695..611594	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVZ66_RS03105	611690..611953	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVZ66_RS03110	612056..612274	+	219	WP_097343043.1	DUF2575 family protein	-
HVZ66_RS03115	612282..613223	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T164785 WP_000935262.1 NZ_CP057104:c608977-608768 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164785 NZ_CP073285:c2791813-2790491 [Klebsiella pneumoniae subsp. ozaenae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCTCTCTCACTGCCGCTGCAGTATGGCAATATCACGG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAA
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTTACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT164785 NZ_CP057104:608969-609026 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin