Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4863923..4864508 Replicon chromosome
Accession NZ_CP056910
Organism Citrobacter freundii strain RHBSTW-00006

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV030_RS23745 Protein ID WP_135912739.1
Coordinates 4863923..4864237 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HV030_RS23750 Protein ID WP_115259723.1
Coordinates 4864230..4864508 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV030_RS23720 4860037..4861617 + 1581 WP_181540146.1 RNA repair transcriptional activator RtcR -
HV030_RS23725 4861722..4861994 + 273 WP_096758747.1 DUF3811 domain-containing protein -
HV030_RS23730 4861991..4862866 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
HV030_RS23735 4863117..4863434 - 318 WP_181540147.1 CcdB family protein -
HV030_RS23740 4863434..4863727 - 294 WP_135912738.1 type II toxin-antitoxin system CcdA family antitoxin -
HV030_RS23745 4863923..4864237 + 315 WP_135912739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV030_RS23750 4864230..4864508 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HV030_RS23755 4864620..4865309 + 690 WP_181638751.1 dipeptidase PepE -
HV030_RS23760 4865438..4867069 - 1632 WP_117343624.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11969.88 Da        Isoelectric Point: 9.5570

>T164497 WP_135912739.1 NZ_CP056910:4863923-4864237 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T164497 NZ_CP072961:595275-595616 [Enterobacter sp. MGH 14]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGAAGCTATGTCTGTCGCCCGTGGCTGTCTGGCAAATGCTGCTTGC
ACTCCTGCTGGAACAACATTATGGCCTGACTCTCAACGACACGCCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACAGGTTTATTGAAAGCGCG
GCACGGTGAACATTGGGAATAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT164497 WP_115259723.1 NZ_CP056910:4864230-4864508 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT164497 NZ_CP072961:594913-595254 [Enterobacter sp. MGH 14]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCCGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGCACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACTCCACCCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References