Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2501489..2502051 Replicon chromosome
Accession NZ_CP056910
Organism Citrobacter freundii strain RHBSTW-00006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV030_RS12110 Protein ID WP_181540888.1
Coordinates 2501773..2502051 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV030_RS12105 Protein ID WP_096757032.1
Coordinates 2501489..2501773 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV030_RS12090 2496790..2499837 + 3048 WP_181638711.1 formate dehydrogenase-N subunit alpha -
HV030_RS12095 2499851..2500735 + 885 WP_115258486.1 formate dehydrogenase N subunit beta -
HV030_RS12100 2500728..2501384 + 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
HV030_RS12105 2501489..2501773 - 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
HV030_RS12110 2501773..2502051 - 279 WP_181540888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV030_RS12115 2502238..2503953 - 1716 WP_181625864.1 ATP-binding cassette domain-containing protein -
HV030_RS12120 2504264..2505961 - 1698 WP_115258488.1 malate dehydrogenase -
HV030_RS12125 2506141..2506281 - 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
HV030_RS12130 2506510..2506941 + 432 WP_096757037.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10611.09 Da        Isoelectric Point: 9.5320

>T164488 WP_181540888.1 NZ_CP056910:c2502051-2501773 [Citrobacter freundii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVPGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T164488 NZ_CP072953:c1189809-1189498 [Enterobacter sp. MGH 3]
ATGCACATAGTCTCAAGAGCGCCTTTCGACACAGCGGCCAGACATTATCCCAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTGAGCGGGGAAAGTTC
TTCATCAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACTACTATCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT164488 WP_096757032.1 NZ_CP056910:c2501773-2501489 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT164488 NZ_CP072953:c1189501-1189082 [Enterobacter sp. MGH 3]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAACTCCCTTTCCTGGGTTCAAGCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGAGATGCTTACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAGTTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTAATGGATCAGTACCAGCTCACTCAGAGCGACTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
AAGTCGGATCCTGAACGGACAGCGCACGTTAACGCTGGATCATATGCGGGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GCGCATTTGTGGGGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References