Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 827773..828561 Replicon chromosome
Accession NZ_CP056910
Organism Citrobacter freundii strain RHBSTW-00006

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV030_RS04040 Protein ID WP_181638367.1
Coordinates 827773..828150 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV030_RS04045 Protein ID WP_181638366.1
Coordinates 828202..828561 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV030_RS04020 824430..825698 - 1269 WP_044346284.1 integrase arm-type DNA-binding domain-containing protein -
HV030_RS04025 826134..826979 - 846 WP_181638370.1 DUF4942 domain-containing protein -
HV030_RS04030 827049..827252 - 204 WP_181638369.1 hypothetical protein -
HV030_RS04035 827285..827776 - 492 WP_181638368.1 hypothetical protein -
HV030_RS04040 827773..828150 - 378 WP_181638367.1 TA system toxin CbtA family protein Toxin
HV030_RS04045 828202..828561 - 360 WP_181638366.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV030_RS04050 828584..828805 - 222 WP_181638365.1 DUF987 domain-containing protein -
HV030_RS04055 828819..829298 - 480 WP_181638364.1 DNA repair protein RadC -
HV030_RS04060 829309..829794 - 486 WP_181638363.1 antirestriction protein -
HV030_RS04065 829811..830065 - 255 WP_101700259.1 hypothetical protein -
HV030_RS04070 830065..830883 - 819 WP_181638362.1 DUF945 domain-containing protein -
HV030_RS04075 830995..831228 - 234 WP_101700257.1 DUF905 domain-containing protein -
HV030_RS04080 831285..831506 - 222 WP_101700256.1 hypothetical protein -
HV030_RS04085 831586..832098 - 513 WP_181638361.1 DUF4234 domain-containing protein -
HV030_RS04090 832144..832614 - 471 WP_181638360.1 hypothetical protein -
HV030_RS04095 832661..832972 - 312 WP_023336630.1 hypothetical protein -
HV030_RS04100 833039..833542 - 504 Protein_805 HTH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 818733..884365 65632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13922.78 Da        Isoelectric Point: 9.0116

>T164477 WP_181638367.1 NZ_CP056910:c828150-827773 [Citrobacter freundii]
MQTRQLSSTREASPRPTPVEIWQTLLTYLLERHYGLSLNDTQFGDGNVIHQHIDAGISLADALNFLVEKSELVRIDRPGF
SIQHQSPFISAIDILRARKATGLMQRTGYKAVTCAISGQSSRGQQ

Download         Length: 378 bp

>T164477 NZ_CP072949:c4691600-4691067 [Klebsiella pneumoniae MGH 39]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13180.08 Da        Isoelectric Point: 6.7424

>AT164477 WP_181638366.1 NZ_CP056910:c828561-828202 [Citrobacter freundii]
MQNPTNVASHDITEPWWGLKPAVIPCFGARLVQEGNRLHYLADRASITGTFSNADLRHLDQAFPVLMKQLELMLLSGELN
PRHQHCVTLYAKGLTCESDTLGSHGYVYLAIYPTSAITA

Download         Length: 360 bp

>AT164477 NZ_CP072949:c4691877-4691611 [Klebsiella pneumoniae MGH 39]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References