Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 59589..60268 Replicon chromosome
Accession NZ_CP056910
Organism Citrobacter freundii strain RHBSTW-00006

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV030_RS00310 Protein ID WP_008324824.1
Coordinates 59589..59930 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV030_RS00315 Protein ID WP_008324825.1
Coordinates 59951..60268 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV030_RS00270 54944..55294 - 351 WP_181540233.1 hypothetical protein -
HV030_RS00275 55512..55814 - 303 WP_115257152.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV030_RS00280 55818..56078 - 261 WP_117342569.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HV030_RS00285 56252..56543 - 292 Protein_56 type I addiction module toxin, SymE family -
HV030_RS00290 56679..56873 + 195 WP_181638399.1 toxin-antitoxin system HicB family antitoxin -
HV030_RS00295 56882..57448 - 567 WP_181540235.1 hypothetical protein -
HV030_RS00300 57688..58553 - 866 Protein_59 virulence RhuM family protein -
HV030_RS00305 58641..59474 - 834 WP_008324823.1 DUF4942 domain-containing protein -
HV030_RS00310 59589..59930 - 342 WP_008324824.1 TA system toxin CbtA family protein Toxin
HV030_RS00315 59951..60268 - 318 WP_008324825.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV030_RS00320 60287..60508 - 222 WP_008324827.1 DUF987 domain-containing protein -
HV030_RS00325 60517..60993 - 477 WP_008324829.1 RadC family protein -
HV030_RS00330 61009..61467 - 459 WP_008324836.1 antirestriction protein -
HV030_RS00335 61553..61789 - 237 WP_008324838.1 DUF905 domain-containing protein -
HV030_RS00340 61867..62277 - 411 WP_008324839.1 hypothetical protein -
HV030_RS00345 62344..62781 - 438 WP_008324840.1 hypothetical protein -
HV030_RS00350 62823..63359 - 537 WP_008324841.1 DUF4339 domain-containing protein -
HV030_RS00355 63385..64095 - 711 WP_008324842.1 DeoR family transcriptional regulator -
HV030_RS00360 64304..65128 - 825 WP_008324843.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12855.96 Da        Isoelectric Point: 9.6548

>T164473 WP_008324824.1 NZ_CP056910:c59930-59589 [Citrobacter freundii]
MKILPATISRAAKPCLPPIAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINTGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRSRNPAAI

Download         Length: 342 bp

>T164473 NZ_CP072949:1837309-1837641 [Klebsiella pneumoniae MGH 39]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11811.34 Da        Isoelectric Point: 5.9451

>AT164473 WP_008324825.1 NZ_CP056910:c60268-59951 [Citrobacter freundii]
MSNITWGLQRDITPRLGTRLVQEGNQLHYLDDRASIVGKFSDAECLKLDVAFPHFISQMESMLTTGEMNSCHAHCVTLYH
NGFTCEADTLGSSGYVYVAVYFTQR

Download         Length: 318 bp

>AT164473 NZ_CP072949:1837051-1837308 [Klebsiella pneumoniae MGH 39]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References