Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2860654..2861256 Replicon chromosome
Accession NZ_CP056779
Organism Enterobacter cloacae strain D41-sc-1712200

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HWQ17_RS13685 Protein ID WP_148422529.1
Coordinates 2860654..2860965 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HWQ17_RS13690 Protein ID WP_148422528.1
Coordinates 2860966..2861256 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ17_RS13655 2855682..2856482 + 801 WP_148422535.1 DeoR/GlpR family DNA-binding transcription regulator -
HWQ17_RS13660 2856601..2857200 + 600 WP_148422534.1 glucose-1-phosphatase -
HWQ17_RS13665 2857194..2858075 + 882 WP_148422533.1 virulence factor BrkB family protein -
HWQ17_RS13670 2858072..2858509 + 438 WP_148422532.1 D-tyrosyl-tRNA(Tyr) deacylase -
HWQ17_RS13675 2858554..2859495 + 942 WP_176609165.1 fatty acid biosynthesis protein FabY -
HWQ17_RS13680 2859507..2860424 - 918 WP_148422530.1 alpha/beta hydrolase -
HWQ17_RS13685 2860654..2860965 + 312 WP_148422529.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWQ17_RS13690 2860966..2861256 + 291 WP_148422528.1 helix-turn-helix domain-containing protein Antitoxin
HWQ17_RS13695 2861298..2862227 - 930 WP_022652077.1 formate dehydrogenase accessory protein FdhE -
HWQ17_RS13700 2862224..2862859 - 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
HWQ17_RS13705 2862856..2863758 - 903 WP_003861960.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12144.12 Da        Isoelectric Point: 9.7548

>T164217 WP_148422529.1 NZ_CP056779:2860654-2860965 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLATQPDYGDLIQNTGGLRKIRWLSGGRGKRGGVRIIYFHRTREFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T164217 NZ_CP072844:c2965324-2965037 [Psychrosphaera aestuarii]
ATGACCTATGAGTTAGAGTTTAATAAATCTGCCTTTAAAGAATGGAAAAAGTTAGGCTCGACAGTAAGAGAACAATTTAA
AAAGAAGTTAAAGGCTGTACTCGATGGGCCTCATATAACTAGTGCAAAGTTAACCGGCGCAAATAACCTTTATAAAATTA
AGTTGAGGCAAGCGGGTTACAGACTGGTTTATGAAGTGCAAGACGAGAAAGTAACCGTCAAAGTGATAACGGTTGGCAAA
AGAGACAAAGGAGAAGTTTATAAAATTGCACAGCACCGAATTAGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10582.13 Da        Isoelectric Point: 11.2132

>AT164217 WP_148422528.1 NZ_CP056779:2860966-2861256 [Enterobacter cloacae]
MDKALFERLTHSIAQMNEIAGGQRAPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT164217 NZ_CP072844:c2965562-2965314 [Psychrosphaera aestuarii]
ATGGCAAATAGAATTTTAACTGAAACGGCCGCGAGCATAAGTGAATTAAAAGCCAATCCTATGAAAGTTGCGTTAAGTGC
AGACGGTGAAGCAATTGCCGTTTTAAATAGGAATGAGCCTGCGTTCTATTGCATTCCAGCAGCAACTTATGAACAAATGA
TTGATCATTTAGAGGATTTAGAATTACTAAGAATCGTCGAGCAGAGACGAGGTGAAGAGTCTATTAAGGTAGGTCTCAAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References