Detailed information of TA system TA164148

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 955861..956618
• Replicon: chromosome
• Accession: NZ_CP056756
• Organism: Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV117_RS04550
• Protein ID: WP_061548225.1
• Coordinates: 955861..956244 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV117_RS04555
• Protein ID: WP_061548224.1
• Coordinates: 956280..956618 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV117_RS04525	951061..951462	+	402	WP_006809999.1	sigma factor-binding protein Crl	-
HV117_RS04530	951594..952646	-	1053	WP_047052447.1	phosphoporin PhoE	-
HV117_RS04535	952952..954055	+	1104	WP_015571369.1	glutamate 5-kinase	-
HV117_RS04540	954067..955320	+	1254	WP_047052448.1	glutamate-5-semialdehyde dehydrogenase	-
HV117_RS04550	955861..956244	-	384	WP_061548225.1	TA system toxin CbtA family protein	Toxin
HV117_RS04555	956280..956618	-	339	WP_061548224.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV117_RS04560	956634..956855	-	222	WP_061548223.1	DUF987 family protein	-
HV117_RS04565	956852..957352	-	501	WP_050555520.1	DNA repair protein RadC	-
HV117_RS04570	957382..958200	-	819	WP_061548222.1	DUF945 domain-containing protein	-
HV117_RS04575	958300..958977	-	678	WP_061548221.1	hypothetical protein	-
HV117_RS04580	959264..960157	-	894	WP_061548220.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-111)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14405.48 Da
• Isoelectric Point: 9.6221

>T164148 WP_061548225.1 NZ_CP056756:c956244-955861 [Enterobacter hormaechei]
MQISTAPTTEPISSRLSPVEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDRSGF
TIMEQSPFISSIDILRARRATGLMKRQGYKSISNITTGHLLQERHLR

Nucleotide

• Length: 384 bp

>T164148 NZ_CP072801:2939048-2939215 [Thiothrix litoralis]
ATGGCTCTGAAAACTTACATGCTGGATACCTGTATTTGCAGTTTTATCCAGCGCGAACAGCCTTTGCAGGTATTACAGCG
TTTACAACAAGCCCGTGATCAGCATGATCAGGTGGTCATTTCCGCGATTACCTATGCAGAAATGCGTTTCGGTGCGACTA
ACAAATAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12577.31 Da
• Isoelectric Point: 6.2162

>AT164148 WP_061548224.1 NZ_CP056756:c956618-956280 [Enterobacter hormaechei]
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSAALDAIFPALIRDMETALLRGKLDPREAKQ
YIYIRNGFTCESDTLGSCGYVYIVIYPQSEAS

Nucleotide

• Length: 339 bp

>AT164148 NZ_CP072801:2938824-2939057 [Thiothrix litoralis]
ATGCGAACTGTATCCATCTTTGCCAACGGCAACAATCAAGCCGTGCGTATCCCTAAAGATATGGAATTTTCCAACCTCAA
AGAGCTGGAAATTTTTCGTGAAGGGGATTCGCTGATTTTGCGCCCGACCCGCCCGGATTGGCTTTCATTCGCCGAACTGG
ATAAGGCGGATGATGATTTTCTCGTGGAACGCCCCGATGTGATGAGCGATGAAGGGCGCTTTGAATGGCTCTGA