Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3611431..3612051 Replicon chromosome
Accession NZ_CP056751
Organism Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV128_RS17560 Protein ID WP_015571250.1
Coordinates 3611833..3612051 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV128_RS17555 Protein ID WP_006809850.1
Coordinates 3611431..3611805 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV128_RS17545 3606559..3607752 + 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV128_RS17550 3607775..3610921 + 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
HV128_RS17555 3611431..3611805 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV128_RS17560 3611833..3612051 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV128_RS17565 3612260..3612811 + 552 WP_017694396.1 maltose O-acetyltransferase -
HV128_RS17570 3612928..3613395 + 468 WP_017383209.1 membrane protein -
HV128_RS17575 3613367..3614827 - 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
HV128_RS17580 3614929..3615639 + 711 WP_047051118.1 GNAT family N-acetyltransferase -
HV128_RS17585 3615636..3615776 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV128_RS17590 3615779..3616039 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T164139 WP_015571250.1 NZ_CP056751:3611833-3612051 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T164139 NZ_CP072800:3186561-3186956 [Candidatus Thiothrix anitrata]
TTGATTTTGGTTGATACCGACGTATTGATTTGGGTAACACGCAAAAACCCGCACGCCAGCGCATTTCTGGACAGCTTCGA
TGACCTTGCCATTTCTGATGTGACTTACATGGAGCTGATTCAGGGTGCAAAAAACAAGCGTGAAGCCCAAGCCATCGACA
AAACGCTCAAAAACATGGCGGTATCGCGCCTGCCAATCAATGACAGCATTTCAGAACGCGCCGTAGCATTGGTTCGCCGC
TATTTCCATAGCCATTCCATGCAACTTGCCGACGCACTAATTGCAGCAACCGCGTTGGAATACGGGCTGGCATTGGCAAC
GGGAAATGCCAAACACTTTGAGGTTGTCGAAGATTTGCAATTACACAAATACACCCCTCAGCCCACCGCGATGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT164139 WP_006809850.1 NZ_CP056751:3611431-3611805 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT164139 NZ_CP072800:3187043-3187357 [Candidatus Thiothrix anitrata]
ATGAGCAAGCGTAACTTGTTTGAAGAATTAAGCACCGCCTTGGTCGAAGCCAAGCAACATTCAGAAGGTAAGCTCACCTT
GCGCACCCATGTTGTGCAACGTACAGGTGTGCCTGAAATTAAACCACAGGAAATTTTGACGATTCGGGAAATGTTCAATA
TGTCACGGGGCGTATTCGCTCGTCACTTACACACATCTGCCCGAACGCTCGAAAGCTGGGAACAGGGACGCACTACCCCT
AATGGTCAGGCAGTAACACTATTGCGTTTGGTGCAACGGCATCCTGAAACCTTATCCTACATTGCCGAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References