Detailed information of TA system TA164138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3103871..3104784
• Replicon: chromosome
• Accession: NZ_CP056751
• Organism: Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV128_RS15080
• Protein ID: WP_047052345.1
• Coordinates: 3104311..3104784 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV128_RS15075
• Protein ID: WP_047052347.1
• Coordinates: 3103871..3104314 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV128_RS15060	3098945..3100666	+	1722	WP_003858307.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
HV128_RS15065	3100712..3101416	+	705	WP_047052381.1	leucyl/phenylalanyl-tRNA--protein transferase	-
HV128_RS15070	3101701..3101919	+	219	WP_002211347.1	translation initiation factor IF-1	-
HV128_RS15075	3103871..3104314	+	444	WP_047052347.1	DUF2384 domain-containing protein	Antitoxin
HV128_RS15080	3104311..3104784	+	474	WP_047052345.1	RES domain-containing protein	Toxin
HV128_RS15085	3104807..3105361	-	555	WP_047052344.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
HV128_RS15090	3105371..3106369	-	999	WP_047052342.1	type I-F CRISPR-associated protein Csy3	-
HV128_RS15095	3106383..3107318	-	936	WP_047052340.1	type I-F CRISPR-associated protein Csy2	-
HV128_RS15100	3107315..3108625	-	1311	WP_181522297.1	type I-F CRISPR-associated protein Csy1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17570.95 Da
• Isoelectric Point: 5.1151

>T164138 WP_047052345.1 NZ_CP056751:3104311-3104784 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFDFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T164138 NZ_CP072800:c2330140-2329562 [Candidatus Thiothrix anitrata]
ATGCTTTCAGGTCAAAATTTTACAGTTTTGTACGATGCCTGTGTGCTTTATCCAGCACCCTTGCGTGATTTTCTGGTGCG
GTTGGCGTGGACGGGTGTATTTCGGGCAAAATGGACGCAACAAATTCATGAAGAATGGATACGCAACACTTTACAGAACA
ACACCAAGCTGACCCGTGAACGTTTGGAAATGACTGCTGGTAAGATGAATGCTGCAATTATGGATTCACTGGTATCAGGT
TATGAACCACTTATTGCTGGTTTAGAATTGCCCGATGTGAATGACAGACATGTATTAGCTGCGGCGATTAAGGGGCAAGC
AGAAGTTATTGTCACGTTTAATCTGAAAGACTTTCCTGCTAGTTACCTAAAACCCTTCGGTATTTTGGCACAACACCCTG
ATGAGTTTATCAGCCACCTGACTAATCTATACCCCGAAATGATTTTACTGACTGCCCGACAACAAAGAGCGAGCTTGAAA
AATCCACCAAGAACTGTCGATGAATTCTTAGATACATTGTTGCGTCAACAGTTGCCCCGCACAGCGGCATTCCTTAAGCA
ACGTAAGGAGCTTATCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16502.77 Da
• Isoelectric Point: 6.4819

>AT164138 WP_047052347.1 NZ_CP056751:3103871-3104314 [Enterobacter hormaechei]
MRTWVPAQRSADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT164138 NZ_CP072800:c2330586-2330140 [Candidatus Thiothrix anitrata]
ATGCCTGCCTTAGTCAGTTATCAAGTCCCGACGCAAGAAGATACCGAGCTTGCTGTTGAGAGCAGCCGTTTGTTGGCTGC
TTGCATTGGCAAAGGAGAAAGTGCTTGTTTACGCCTTCATAACGGCAATGAACTGCTGCAAGTTCCCGTAAAAGCGATTC
GCTTGTTGGTGGACATTTTGGATGCAATGGCGCGAGGTGATGCCGTATCTCTCATTCCGATCCACAAAGAATTGACCACC
CAAGAAGCAGCTAACATCTTAAATGTTTCACGTCCCTATTTAGTAAAGTTGATGGAAGCTGGGGAAATACCATTTCATAA
GAATGGAGTACGTCGTCGCGTTTTCTTTAAAGACTTAATGGAGTACAAGCAAAAACGGGATCAGGCCAATATGCTGCTAC
TGGATGAGTTGACTGCCGAAGCCCAAGAATTTGAGATGGGTTACTAA