Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 88907..89563 Replicon chromosome
Accession NZ_CP056751
Organism Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV128_RS00480 Protein ID WP_080344062.1
Coordinates 88907..89299 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV128_RS00485 Protein ID WP_047050676.1
Coordinates 89303..89563 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV128_RS00455 84567..85202 - 636 WP_047050682.1 LuxR family transcriptional regulator -
HV128_RS00460 85773..86393 + 621 WP_047050680.1 response regulator transcription factor -
HV128_RS00465 86469..87149 + 681 WP_047050679.1 EAL domain-containing protein -
HV128_RS00470 87183..87983 - 801 WP_047050678.1 lipoprotein NlpA -
HV128_RS00475 88365..88838 + 474 WP_032674176.1 hypothetical protein -
HV128_RS00480 88907..89299 - 393 WP_080344062.1 type II toxin-antitoxin system VapC family toxin Toxin
HV128_RS00485 89303..89563 - 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV128_RS00490 89681..91180 - 1500 WP_112778513.1 MFS transporter -
HV128_RS00495 91259..91906 + 648 WP_017383663.1 TetR/AcrR family transcriptional regulator -
HV128_RS00500 91903..92322 - 420 WP_047050673.1 GNAT family N-acetyltransferase -
HV128_RS00505 92508..93077 + 570 WP_032103771.1 TetR/AcrR family transcriptional regulator -
HV128_RS00510 93225..94346 + 1122 WP_047050671.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 78456..89563 11107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14585.78 Da        Isoelectric Point: 5.8985

>T164123 WP_080344062.1 NZ_CP056751:c89299-88907 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Download         Length: 393 bp

>T164123 NZ_CP072793:c2158791-2158510 [Thiothrix unzii]
ATGACAAAATTTACCCCATTTGATGCGGCTGATTATCTTGATGATGAAGAGACTATCGCTGCTTATTTATCCGAGGCACT
TGAAGACCCTGACCCTGATACATTCCTGATGGCTGTCAGAACCGTTGCCCGCGCCCGTGGCATGACACAACTGGCTAAAG
ATTCAGGGCTTGGGCGGGAGAGCCTTTATAAAGCCCTGACACCTGGTGCAAAACCCCGTTATGACACAATGATGAAGGTG
ATTCGTGCGCTTGGGATCAAATTACACGCCGAAGCTGCTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT164123 WP_047050676.1 NZ_CP056751:c89563-89303 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT164123 NZ_CP072793:c2159096-2158788 [Thiothrix unzii]
ATGAACATCATCCTCAAGTCAGACAAGTTCGATGATTGGTTATCCAATCTGAGAGACAAAAAAGCAAAAGCCAAGATTGC
TTTACGGCTTGGGCGGGCTGAACAAGGTAACTTTGGTGATTGTGAGCCTGTCGGCGAGGGTGTGTCTGAGATGCGCATCC
ATTACGGCCCCGGCTACCGCCTTTATTTCACCCGCCGGGGTGATGTCGTTTATTTATTGTTATTGGGTGGCGACAAATCG
ACCCAACAAACTGACATCAAGAGAGCCATAGAGATGGCTAACAATCTGCCCAAGGAATCAACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References