Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 1638987..1640770 Replicon chromosome
Accession NZ_CP056742
Organism Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV132_RS07920 Protein ID WP_047053382.1
Coordinates 1639421..1640770 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV132_RS07915 Protein ID WP_047053381.1
Coordinates 1638987..1639424 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV132_RS07895 1634006..1635028 + 1023 WP_047053378.1 HTH-type transcriptional regulator GalS -
HV132_RS07900 1635324..1636322 + 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
HV132_RS07905 1636402..1637922 + 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
HV132_RS07910 1637938..1638948 + 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
HV132_RS07915 1638987..1639424 - 438 WP_047053381.1 helix-turn-helix domain-containing protein Antitoxin
HV132_RS07920 1639421..1640770 - 1350 WP_047053382.1 type II toxin-antitoxin system HipA family toxin Toxin
HV132_RS07925 1640905..1641615 - 711 WP_003859314.1 outer membrane permeability protein SanA -
HV132_RS07930 1641743..1642627 - 885 WP_047053384.1 cytidine deaminase -
HV132_RS07935 1642756..1643451 - 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
HV132_RS07940 1643448..1643843 - 396 WP_023295055.1 CidA/LrgA family protein -
HV132_RS07945 1644012..1644947 + 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-129)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51132.76 Da        Isoelectric Point: 4.6556

>T164084 WP_047053382.1 NZ_CP056742:c1640770-1639421 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Download         Length: 1350 bp

>T164084 NZ_CP072790:c2190403-2190074 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16161.57 Da        Isoelectric Point: 10.5154

>AT164084 WP_047053381.1 NZ_CP056742:c1639424-1638987 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT164084 NZ_CP072790:c2190777-2190400 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References