Detailed information of TA system TA163948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4541918..4542737
• Replicon: chromosome
• Accession: NZ_CP056701
• Organism: Klebsiella grimontii strain RHBSTW-00577

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: HV240_RS21800
• Protein ID: WP_181512011.1
• Coordinates: 4542480..4542737 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: HV240_RS21795
• Protein ID: WP_004132606.1
• Coordinates: 4541918..4542469 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV240_RS21780	4537307..4538704	+	1398	WP_004132593.1	MFS transporter	-
HV240_RS21785	4538828..4540168	+	1341	WP_049088521.1	carbohydrate porin	-
HV240_RS21790	4540272..4541900	-	1629	WP_049088522.1	SAM-dependent methyltransferase	-
HV240_RS21795	4541918..4542469	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
HV240_RS21800	4542480..4542737	-	258	WP_181512011.1	YjhX family toxin	Toxin
HV240_RS21805	4543321..4544505	+	1185	WP_049085652.1	mannonate dehydratase	-
HV240_RS21810	4544582..4546057	+	1476	WP_049130810.1	fructuronate reductase	-
HV240_RS21815	4546194..4546970	+	777	WP_116944170.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9614.14 Da
• Isoelectric Point: 10.9564

>T163948 WP_181512011.1 NZ_CP056701:c4542737-4542480 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTYVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T163948 NZ_CP072765:3188379-3188822 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT163948 WP_004132606.1 NZ_CP056701:c4542469-4541918 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT163948 NZ_CP072765:3188135-3188392 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA