Detailed information of TA system TA163906

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 598110..598368
• Replicon: chromosome
• Accession: NZ_CP056697
• Organism: Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV246_RS02795
• Protein ID: WP_000935262.1
• Coordinates: 598110..598319 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	598311..598368 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV246_RS02775	593435..594001	-	567	WP_000528538.1	acetate uptake transporter	-
HV246_RS02780	594241..594493	-	253	Protein_534	DUF2541 family protein	-
HV246_RS02785	594870..596786	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV246_RS02790	596875..598005	+	1131	WP_001118463.1	molecular chaperone DnaJ	-
HV246_RS02795	598110..598319	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	598311..598368	+	58	-	-	Antitoxin
HV246_RS02800	598846..600012	+	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
HV246_RS02805	600072..600977	+	906	WP_000062876.1	transcriptional activator NhaR	-
HV246_RS02810	601080..601343	-	264	WP_001274018.1	30S ribosomal protein S20	-
HV246_RS02815	601446..601664	+	219	Protein_541	DUF2575 domain-containing protein	-
HV246_RS02820	601672..602613	+	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T163906 WP_000935262.1 NZ_CP056697:c598319-598110 [Escherichia marmotae]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T163906 NZ_CP072765:716667-717062 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT163906 NZ_CP056697:598311-598368 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin