Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4466584..4467100 Replicon chromosome
Accession NZ_CP056573
Organism Citrobacter freundii strain RHBSTW-00370

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag HV178_RS21565 Protein ID WP_003839578.1
Coordinates 4466584..4466868 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag HV178_RS21570 Protein ID WP_003839576.1
Coordinates 4466858..4467100 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV178_RS21550 4462831..4463415 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
HV178_RS21555 4463793..4465931 + 2139 WP_048234081.1 anaerobic ribonucleoside-triphosphate reductase -
HV178_RS21560 4466116..4466580 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV178_RS21565 4466584..4466868 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV178_RS21570 4466858..4467100 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV178_RS21575 4467178..4469091 - 1914 WP_003839574.1 BglG family transcription antiterminator -
HV178_RS21580 4469113..4469853 - 741 WP_003025772.1 KDGP aldolase family protein -
HV178_RS21585 4469850..4470968 - 1119 WP_048234082.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HV178_RS21590 4470952..4472085 - 1134 WP_048234085.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T163717 WP_003839578.1 NZ_CP056573:c4466868-4466584 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T163717 NZ_CP072761:3875050-3875460 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTCGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT163717 WP_003839576.1 NZ_CP056573:c4467100-4466858 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT163717 NZ_CP072761:3874775-3875053 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References