Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3990651..3991270 Replicon chromosome
Accession NZ_CP056329
Organism Klebsiella pneumoniae strain RHBSTW-00807

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV282_RS19750 Protein ID WP_002892050.1
Coordinates 3991052..3991270 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV282_RS19745 Protein ID WP_002892066.1
Coordinates 3990651..3991025 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV282_RS19735 3985803..3986996 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV282_RS19740 3987019..3990165 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV282_RS19745 3990651..3991025 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV282_RS19750 3991052..3991270 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV282_RS19755 3991429..3991995 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV282_RS19760 3991967..3992107 - 141 WP_004147370.1 hypothetical protein -
HV282_RS19765 3992128..3992598 + 471 WP_002892026.1 YlaC family protein -
HV282_RS19770 3992573..3994024 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HV282_RS19775 3994125..3994823 + 699 WP_038807562.1 GNAT family N-acetyltransferase -
HV282_RS19780 3994820..3994960 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV282_RS19785 3994960..3995223 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163303 WP_002892050.1 NZ_CP056329:3991052-3991270 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163303 NZ_CP072515:c3175295-3175193 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT163303 WP_002892066.1 NZ_CP056329:3990651-3991025 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163303 NZ_CP072515:3175189-3175336 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References