Detailed information of TA system TA163048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4180677..4181193
• Replicon: chromosome
• Accession: NZ_CP056229
• Organism: Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5I6CHB9
• Locus tag: HV337_RS19800
• Protein ID: WP_000220581.1
• Coordinates: 4180677..4180961 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV337_RS19805
• Protein ID: WP_115259576.1
• Coordinates: 4180951..4181193 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV337_RS19785	4175878..4177530	+	1653	WP_181490669.1	alpha,alpha-phosphotrehalase	-
HV337_RS19790	4177949..4180087	+	2139	WP_115259574.1	anaerobic ribonucleoside-triphosphate reductase	-
HV337_RS19795	4180209..4180673	+	465	WP_096759476.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV337_RS19800	4180677..4180961	-	285	WP_000220581.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV337_RS19805	4180951..4181193	-	243	WP_115259576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV337_RS19810	4181271..4183184	-	1914	WP_181490670.1	BglG family transcription antiterminator	-
HV337_RS19815	4183206..4183946	-	741	WP_146717606.1	KDGP aldolase family protein	-
HV337_RS19820	4183943..4185061	-	1119	WP_146717607.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
HV337_RS19825	4185045..4186178	-	1134	WP_137400483.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10868.70 Da
• Isoelectric Point: 10.0482

>T163048 WP_000220581.1 NZ_CP056229:c4180961-4180677 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T163048 NZ_CP072305:456643-457032 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAACTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAACAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8947.32 Da
• Isoelectric Point: 5.0490

>AT163048 WP_115259576.1 NZ_CP056229:c4181193-4180951 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLDKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT163048 NZ_CP072305:456379-456636 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: A0A5I6CHB9