Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1233259..1233877 Replicon chromosome
Accession NZ_CP056165
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HV276_RS05840 Protein ID WP_001280991.1
Coordinates 1233259..1233477 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag HV276_RS05845 Protein ID WP_000344801.1
Coordinates 1233482..1233877 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS05805 1228553..1229125 + 573 WP_001515895.1 YbaY family lipoprotein -
HV276_RS05810 1229156..1229467 - 312 WP_172954571.1 MGMT family protein -
HV276_RS05820 1229847..1230200 + 354 WP_000878149.1 DUF1428 domain-containing protein -
HV276_RS05825 1230237..1231787 - 1551 WP_001515896.1 EAL domain-containing protein -
HV276_RS05830 1231951..1232421 - 471 WP_001515897.1 YlaC family protein -
HV276_RS05835 1232536..1233087 - 552 WP_105224631.1 maltose O-acetyltransferase -
HV276_RS05840 1233259..1233477 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HV276_RS05845 1233482..1233877 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
HV276_RS05850 1234434..1237583 - 3150 WP_001132495.1 multidrug efflux RND transporter permease subunit -
HV276_RS05855 1237606..1238799 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T162851 WP_001280991.1 NZ_CP056165:c1233477-1233259 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162851 NZ_CP072141:2680025-2680327 [Rhizobium sp. L51/94]
ATGACCTCAGACACCAGACTTTTCGACGCTTCCGAGGTTCTCGACAGCGAGAGTGCAATCGATGAATTTCTCGCTGCGGC
ATTCGAAACCGAGGACCCGGCATTTATCGCCAAAAGTCTTGGGGTGATTGCCAAAACCCGAAACATGAGCGCGATCGCCC
GAGATGTTGGAATGAGCCGTGCTGCCCTCTACAAATCGTTGAGCGGCAAAGGCAATCCGGAATTTGCGACCATTATAAAG
GTTATGAAGGCACTTGGCCTCGGCCTGGCTCCTGTCTCTCGGTCTAACCAGGGCGCTGCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT162851 WP_000344801.1 NZ_CP056165:c1233877-1233482 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp

>AT162851 NZ_CP072141:2679723-2680028 [Rhizobium sp. L51/94]
GTGTTCGTTATCCAGCGCACCGAAATCTTCCAGCAGTGGATTATGCGACTGAAGGATCGTAGCGCCGCCGCTCGCATTGC
ATCGCGCATTTTGCGCGCGGAAGACGGTAACCTGCGTGACGTCAAACCTGTCGGAGATGGCGTCGAGGAAATGCGTATCG
ACTACGGGCCGGGCTACAGGATCTATTTCCTCAGACGGCGCTCGGTGTTTGTCGTTCTTCTCGTCGGCGGCGACAAGAGC
ACGCAGCGAAGAGACATCATCGAAGCAAAGCGCCTTTGTGCCGAATGGAAGGAGCGGAACCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References