Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 37056..37581 | Replicon | plasmid pRHBSTW-00844_3 |
| Accession | NZ_CP056157 | ||
| Organism | Enterobacter hormaechei strain RHBSTW-00844 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A7H9K2T5 |
| Locus tag | HV295_RS23185 | Protein ID | WP_045616569.1 |
| Coordinates | 37276..37581 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A8H9ZZC6 |
| Locus tag | HV295_RS23180 | Protein ID | WP_016240352.1 |
| Coordinates | 37056..37274 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV295_RS23145 | 32736..33500 | + | 765 | WP_032192077.1 | GntR family transcriptional regulator | - |
| HV295_RS23150 | 33601..34353 | - | 753 | Protein_38 | VOC family protein | - |
| HV295_RS23155 | 34350..34679 | - | 330 | Protein_39 | L-2-amino-thiazoline-4-carboxylic acid hydrolase | - |
| HV295_RS23160 | 34745..35449 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HV295_RS23165 | 35455..35688 | + | 234 | WP_089617563.1 | helix-turn-helix domain-containing protein | - |
| HV295_RS23170 | 35786..36202 | - | 417 | WP_021312768.1 | type II toxin-antitoxin system VapC family toxin | - |
| HV295_RS23175 | 36199..36429 | - | 231 | WP_021312767.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| HV295_RS23180 | 37056..37274 | + | 219 | WP_016240352.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| HV295_RS23185 | 37276..37581 | + | 306 | WP_045616569.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| HV295_RS23190 | 37751..38728 | + | 978 | Protein_46 | hypothetical protein | - |
| HV295_RS23195 | 38964..39758 | + | 795 | WP_016240356.1 | site-specific integrase | - |
| HV295_RS23200 | 40227..40406 | - | 180 | WP_006788217.1 | hypothetical protein | - |
| HV295_RS23205 | 40526..40636 | - | 111 | Protein_49 | cobyrinic acid ac-diamide synthase | - |
| HV295_RS23210 | 40755..41875 | + | 1121 | WP_085950818.1 | IS3-like element ISSen4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA | 1..125868 | 125868 | |
| - | flank | IS/Tn | - | - | 34745..35449 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11571.24 Da Isoelectric Point: 6.4650
>T162818 WP_045616569.1 NZ_CP056157:37276-37581 [Enterobacter hormaechei]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T162818 NZ_CP072119:c5048922-5048665 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8321.25 Da Isoelectric Point: 4.5358
>AT162818 WP_016240352.1 NZ_CP056157:37056-37274 [Enterobacter hormaechei]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW
Download Length: 219 bp
>AT162818 NZ_CP072119:c5048654-5048103 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTGCTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTGCTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|