Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2807718..2809501 Replicon chromosome
Accession NZ_CP056155
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV295_RS13660 Protein ID WP_047053382.1
Coordinates 2807718..2809067 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV295_RS13665 Protein ID WP_047053381.1
Coordinates 2809064..2809501 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS13635 2803541..2804476 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
HV295_RS13640 2804645..2805040 + 396 WP_023295055.1 CidA/LrgA family protein -
HV295_RS13645 2805037..2805732 + 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
HV295_RS13650 2805861..2806745 + 885 WP_047053384.1 cytidine deaminase -
HV295_RS13655 2806873..2807583 + 711 WP_003859314.1 outer membrane permeability protein SanA -
HV295_RS13660 2807718..2809067 + 1350 WP_047053382.1 type II toxin-antitoxin system HipA family toxin Toxin
HV295_RS13665 2809064..2809501 + 438 WP_047053381.1 helix-turn-helix domain-containing protein Antitoxin
HV295_RS13670 2809540..2810550 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
HV295_RS13675 2810566..2812086 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
HV295_RS13680 2812166..2813164 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
HV295_RS13685 2813460..2814482 - 1023 WP_047053378.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-129)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51132.76 Da        Isoelectric Point: 4.6556

>T162812 WP_047053382.1 NZ_CP056155:2807718-2809067 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Download         Length: 1350 bp

>T162812 NZ_CP072119:c908900-908523 [Klebsiella michiganensis]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16161.57 Da        Isoelectric Point: 10.5154

>AT162812 WP_047053381.1 NZ_CP056155:2809064-2809501 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT162812 NZ_CP072119:c909276-908950 [Klebsiella michiganensis]
ATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTTTGGCGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACGCGGATTTACGCCATCTCGACCAGGCATTCCCGC
TACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGTCTATCTCGCAATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References