Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2022508..2023247 Replicon chromosome
Accession NZ_CP056155
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV295_RS09815 Protein ID WP_045329830.1
Coordinates 2022508..2022993 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV295_RS09820 Protein ID WP_047050951.1
Coordinates 2022981..2023247 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS09795 2018661..2019419 - 759 WP_047050948.1 trans-aconitate 2-methyltransferase -
HV295_RS09800 2019504..2020088 - 585 WP_047050949.1 NUDIX domain-containing protein -
HV295_RS09805 2020175..2020933 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
HV295_RS09810 2021038..2022330 + 1293 WP_047050950.1 glycoside hydrolase -
HV295_RS09815 2022508..2022993 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
HV295_RS09820 2022981..2023247 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
HV295_RS09825 2023311..2024240 - 930 WP_047050986.1 LysR family transcriptional regulator -
HV295_RS09830 2024370..2025758 + 1389 WP_047050952.1 MFS transporter -
HV295_RS09835 2025780..2026775 - 996 WP_047050954.1 DUF2891 domain-containing protein -
HV295_RS09840 2026785..2027771 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T162802 WP_045329830.1 NZ_CP056155:c2022993-2022508 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T162802 NZ_CP072116:2461599-2461865 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT162802 WP_047050951.1 NZ_CP056155:c2023247-2022981 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT162802 NZ_CP072116:2461348-2461599 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References