Detailed information of TA system TA162800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1299691..1300604
• Replicon: chromosome
• Accession: NZ_CP056155
• Organism: Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV295_RS06160
• Protein ID: WP_047052345.1
• Coordinates: 1299691..1300164 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV295_RS06165
• Protein ID: WP_047052347.1
• Coordinates: 1300161..1300604 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV295_RS06140	1295850..1297160	+	1311	WP_047052339.1	type I-F CRISPR-associated protein Csy1	-
HV295_RS06145	1297157..1298092	+	936	WP_047052340.1	type I-F CRISPR-associated protein Csy2	-
HV295_RS06150	1298106..1299104	+	999	WP_047052342.1	type I-F CRISPR-associated protein Csy3	-
HV295_RS06155	1299114..1299668	+	555	WP_047052344.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
HV295_RS06160	1299691..1300164	-	474	WP_047052345.1	RES domain-containing protein	Toxin
HV295_RS06165	1300161..1300604	-	444	WP_047052347.1	DUF2384 domain-containing protein	Antitoxin
HV295_RS06170	1302556..1302774	-	219	WP_002211347.1	translation initiation factor IF-1	-
HV295_RS06175	1303059..1303763	-	705	WP_047052381.1	leucyl/phenylalanyl-tRNA--protein transferase	-
HV295_RS06180	1303809..1305530	-	1722	WP_003858307.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17570.95 Da
• Isoelectric Point: 5.1151

>T162800 WP_047052345.1 NZ_CP056155:c1300164-1299691 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFDFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T162800 NZ_CP072116:2404857-2405123 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16502.77 Da
• Isoelectric Point: 6.4819

>AT162800 WP_047052347.1 NZ_CP056155:c1300604-1300161 [Enterobacter hormaechei]
MRTWVPAQRSADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT162800 NZ_CP072116:2404600-2404857 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA