Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 307267..307863 Replicon chromosome
Accession NZ_CP056155
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag HV295_RS01495 Protein ID WP_023315213.1
Coordinates 307561..307863 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag HV295_RS01490 Protein ID WP_022650216.1
Coordinates 307267..307554 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS01485 305639..307270 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
HV295_RS01490 307267..307554 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
HV295_RS01495 307561..307863 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV295_RS01500 308061..308933 + 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
HV295_RS01505 308934..309206 - 273 WP_047052050.1 DUF3811 domain-containing protein -
HV295_RS01510 309257..310201 - 945 WP_032627014.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV295_RS01515 310295..311644 - 1350 WP_045344657.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T162798 WP_023315213.1 NZ_CP056155:c307863-307561 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T162798 NZ_CP072116:c172444-172349 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT162798 WP_022650216.1 NZ_CP056155:c307554-307267 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT162798 NZ_CP072116:172264-172321 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References