Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 88908..89564 Replicon chromosome
Accession NZ_CP056155
Organism Enterobacter hormaechei strain RHBSTW-00844

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV295_RS00480 Protein ID WP_080344062.1
Coordinates 88908..89300 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV295_RS00485 Protein ID WP_047050676.1
Coordinates 89304..89564 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV295_RS00455 84568..85203 - 636 WP_047050682.1 LuxR family transcriptional regulator -
HV295_RS00460 85774..86394 + 621 WP_047050680.1 response regulator transcription factor -
HV295_RS00465 86470..87150 + 681 WP_047050679.1 EAL domain-containing protein -
HV295_RS00470 87184..87984 - 801 WP_047050678.1 lipoprotein NlpA -
HV295_RS00475 88366..88839 + 474 WP_032674176.1 hypothetical protein -
HV295_RS00480 88908..89300 - 393 WP_080344062.1 type II toxin-antitoxin system VapC family toxin Toxin
HV295_RS00485 89304..89564 - 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV295_RS00490 89682..91181 - 1500 WP_112778513.1 MFS transporter -
HV295_RS00495 91260..91907 + 648 WP_017383663.1 TetR/AcrR family transcriptional regulator -
HV295_RS00500 91904..92323 - 420 WP_047050673.1 GNAT family N-acetyltransferase -
HV295_RS00505 92509..93078 + 570 WP_032103771.1 TetR/AcrR family transcriptional regulator -
HV295_RS00510 93226..94347 + 1122 WP_047050671.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 78457..89564 11107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14585.78 Da        Isoelectric Point: 5.8985

>T162797 WP_080344062.1 NZ_CP056155:c89300-88908 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Download         Length: 393 bp

>T162797 NZ_CP072116:121661-121813 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT162797 WP_047050676.1 NZ_CP056155:c89564-89304 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT162797 NZ_CP072116:121037-121636 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References