Detailed information of TA system TA162736

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3777956..3778613
• Replicon: chromosome
• Accession: NZ_CP056132
• Organism: Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A179PSF7
• Locus tag: HV326_RS18080
• Protein ID: WP_017382887.1
• Coordinates: 3777956..3778366 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HV326_RS18085
• Protein ID: WP_181522420.1
• Coordinates: 3778347..3778613 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV326_RS18060	3773954..3775687	-	1734	WP_047050807.1	single-stranded-DNA-specific exonuclease RecJ	-
HV326_RS18065	3775693..3776406	-	714	WP_003863443.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV326_RS18070	3776435..3777331	-	897	WP_047050805.1	site-specific tyrosine recombinase XerD	-
HV326_RS18075	3777433..3777954	+	522	WP_015571793.1	flavodoxin FldB	-
HV326_RS18080	3777956..3778366	-	411	WP_017382887.1	protein YgfX	Toxin
HV326_RS18085	3778347..3778613	-	267	WP_181522420.1	FAD assembly factor SdhE	Antitoxin
HV326_RS18090	3778908..3779888	+	981	WP_022649306.1	tRNA-modifying protein YgfZ	-
HV326_RS18095	3780000..3780659	-	660	WP_047050804.1	hemolysin III family protein	-
HV326_RS18100	3780926..3781657	+	732	WP_047050802.1	MurR/RpiR family transcriptional regulator	-
HV326_RS18105	3781774..3783207	+	1434	WP_023295383.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16321.21 Da
• Isoelectric Point: 11.4775

>T162736 WP_017382887.1 NZ_CP056132:c3778366-3777956 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T162736 NZ_CP071988:1948107-1948295 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.99 Da
• Isoelectric Point: 4.8310

>AT162736 WP_181522420.1 NZ_CP056132:c3778613-3778347 [Enterobacter hormaechei]
MDINNKTRIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT162736 NZ_CP071988:1947825-1948082 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Structures

Toxin

• AlphaFold DB: A0A179PSF7