Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2317553..2318292 Replicon chromosome
Accession NZ_CP056132
Organism Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV326_RS11200 Protein ID WP_180255983.1
Coordinates 2317553..2318038 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV326_RS11205 Protein ID WP_047050951.1
Coordinates 2318026..2318292 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV326_RS11180 2312946..2313635 - 690 Protein_2180 RNA polymerase subunit sigma-70 -
HV326_RS11185 2313637..2315193 - 1557 Protein_2181 DEAD/DEAH box helicase family protein -
HV326_RS11190 2315250..2316218 - 969 WP_000654804.1 IS5-like element IS903B family transposase -
HV326_RS11195 2316251..2316931 - 681 Protein_2183 restriction endonuclease -
HV326_RS11200 2317553..2318038 - 486 WP_180255983.1 GNAT family N-acetyltransferase Toxin
HV326_RS11205 2318026..2318292 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
HV326_RS11210 2318356..2319285 - 930 WP_047050986.1 LysR family transcriptional regulator -
HV326_RS11215 2319415..2320803 + 1389 WP_047050952.1 MFS transporter -
HV326_RS11220 2320825..2321820 - 996 WP_047050954.1 DUF2891 domain-containing protein -
HV326_RS11225 2321830..2322816 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2220833..2331837 111004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17542.21 Da        Isoelectric Point: 9.9658

>T162724 WP_180255983.1 NZ_CP056132:c2318038-2317553 [Enterobacter hormaechei]
VGRVTAPEPLSSTHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T162724 NZ_CP071982:c914758-914522 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGCTCCCAAGTATAGAGATCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATTTAAAAAACAAGAAAACACTCTTTTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT162724 WP_047050951.1 NZ_CP056132:c2318292-2318026 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT162724 NZ_CP071982:c914441-914190 [Helicobacter pylori]
ATGCCAAACACCACCAAAAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATTAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGTGAAAATTTAGAGGTTATTGAAGACTTTTCTGCATGGACCAATGAAAGAAAAAAGGAAGTGAAT
GCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References