Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4123218..4123734 Replicon chromosome
Accession NZ_CP056129
Organism Enterobacter roggenkampii strain RHBSTW-00925

Toxin (Protein)


Gene name relE Uniprot ID A0A0W2HDR3
Locus tag HV328_RS19770 Protein ID WP_008501399.1
Coordinates 4123218..4123502 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag HV328_RS19775 Protein ID WP_008501400.1
Coordinates 4123492..4123734 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV328_RS19755 4119564..4120136 + 573 WP_047747541.1 fructose PTS transporter subunit IIA -
HV328_RS19760 4120506..4122644 + 2139 WP_008501397.1 anaerobic ribonucleoside-triphosphate reductase -
HV328_RS19765 4122750..4123214 + 465 WP_045408172.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV328_RS19770 4123218..4123502 - 285 WP_008501399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV328_RS19775 4123492..4123734 - 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV328_RS19780 4123812..4125722 - 1911 WP_181519005.1 BglG family transcription antiterminator -
HV328_RS19785 4125742..4126878 - 1137 WP_181519006.1 lactonase family protein -
HV328_RS19790 4126904..4127644 - 741 WP_021240686.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10768.53 Da        Isoelectric Point: 10.3039

>T162712 WP_008501399.1 NZ_CP056129:c4123502-4123218 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Download         Length: 285 bp

>T162712 NZ_CP071970:533604-533954 [Bacillus amyloliquefaciens]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT162712 WP_008501400.1 NZ_CP056129:c4123734-4123492 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT162712 NZ_CP071970:533317-533598 [Bacillus amyloliquefaciens]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W2HDR3

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References