Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3456442..3457091 Replicon chromosome
Accession NZ_CP056129
Organism Enterobacter roggenkampii strain RHBSTW-00925

Toxin (Protein)


Gene name higB Uniprot ID A0A1S2AEP5
Locus tag HV328_RS16665 Protein ID WP_045416590.1
Coordinates 3456442..3456804 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S2AD04
Locus tag HV328_RS16670 Protein ID WP_047746098.1
Coordinates 3456792..3457091 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV328_RS16645 3451778..3452749 - 972 WP_021241589.1 LacI family transcriptional regulator -
HV328_RS16650 3452825..3453967 - 1143 WP_047746102.1 Gfo/Idh/MocA family oxidoreductase -
HV328_RS16655 3453960..3454985 - 1026 WP_047746100.1 sugar phosphate isomerase/epimerase -
HV328_RS16660 3455001..3456236 - 1236 WP_032663994.1 MFS transporter -
HV328_RS16665 3456442..3456804 + 363 WP_045416590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV328_RS16670 3456792..3457091 + 300 WP_047746098.1 helix-turn-helix transcriptional regulator Antitoxin
HV328_RS16675 3457202..3458590 - 1389 WP_047746095.1 phenylalanine transporter -
HV328_RS16680 3458694..3460667 - 1974 WP_048962785.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13908.76 Da        Isoelectric Point: 5.1960

>T162709 WP_045416590.1 NZ_CP056129:3456442-3456804 [Enterobacter roggenkampii]
MWNVETTDRFDDWFFEQTTALKEDVLATMHILAEFGPTLGRPYVDTVKDSAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMIALADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T162709 NZ_CP071959:c210713-210561 [Enterococcus faecium]
ATTGAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATTTCATCATCATCTTTATAAGGATGGTGTTAGAATCACTGT
TCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCGAAAAATTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10906.70 Da        Isoelectric Point: 9.8627

>AT162709 WP_047746098.1 NZ_CP056129:3456792-3457091 [Enterobacter roggenkampii]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT162709 NZ_CP071959:c210527-210096 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGCTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2AEP5

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2AD04

References