Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2875506..2876127 Replicon chromosome
Accession NZ_CP056118
Organism Enterobacter sp. DSM 30060

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HWQ15_RS13660 Protein ID WP_015571250.1
Coordinates 2875506..2875724 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HWQ15_RS13665 Protein ID WP_006809850.1
Coordinates 2875753..2876127 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ15_RS13630 2871518..2871778 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HWQ15_RS13635 2871781..2871921 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HWQ15_RS13640 2871918..2872628 - 711 WP_063149169.1 GNAT family N-acetyltransferase -
HWQ15_RS13645 2872731..2874191 + 1461 WP_063149170.1 PLP-dependent aminotransferase family protein -
HWQ15_RS13650 2874163..2874630 - 468 WP_022647269.1 hypothetical protein -
HWQ15_RS13655 2874747..2875298 - 552 WP_022647270.1 maltose O-acetyltransferase -
HWQ15_RS13660 2875506..2875724 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HWQ15_RS13665 2875753..2876127 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HWQ15_RS13670 2876637..2879783 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HWQ15_RS13675 2879806..2880999 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T162655 WP_015571250.1 NZ_CP056118:c2875724-2875506 [Enterobacter sp. DSM 30060]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T162655 NZ_CP071936:977301-977561 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGAGTTTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAACGAGTTGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT162655 WP_006809850.1 NZ_CP056118:c2876127-2875753 [Enterobacter sp. DSM 30060]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT162655 NZ_CP071936:976955-977320 [Helicobacter pylori]
ATGCCAAACACCACCAAAAAAGATTACACCCAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAGAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAAGTTTCA
CTATCAAGTTAGAAGAATTGAACAAAATCTTACAAGAAATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTCAACAAAGAAACCGATTTGATTGTTGAGGATTTTTCTAGTTA
TAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References