Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1759038..1759768 | Replicon | chromosome |
| Accession | NZ_CP056118 | ||
| Organism | Enterobacter sp. DSM 30060 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A155SSD8 |
| Locus tag | HWQ15_RS08330 | Protein ID | WP_022646552.1 |
| Coordinates | 1759038..1759352 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HWQ15_RS08335 | Protein ID | WP_022646553.1 |
| Coordinates | 1759349..1759768 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWQ15_RS08305 | 1755119..1756204 | + | 1086 | Protein_1609 | cellulase family glycosylhydrolase | - |
| HWQ15_RS08310 | 1756110..1757294 | - | 1185 | WP_023298963.1 | multidrug efflux MFS transporter EmrD | - |
| HWQ15_RS08315 | 1757470..1757888 | - | 419 | Protein_1611 | EamA family transporter | - |
| HWQ15_RS08320 | 1757951..1758397 | - | 447 | WP_023298965.1 | GNAT family N-acetyltransferase | - |
| HWQ15_RS08325 | 1758462..1758551 | - | 90 | WP_022646551.1 | type I toxin-antitoxin system toxin TisB | - |
| HWQ15_RS08330 | 1759038..1759352 | + | 315 | WP_022646552.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| HWQ15_RS08335 | 1759349..1759768 | + | 420 | WP_022646553.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HWQ15_RS08340 | 1759915..1760013 | + | 99 | WP_057979964.1 | ilvB operon leader peptide IvbL | - |
| HWQ15_RS08345 | 1760120..1761808 | + | 1689 | WP_063148988.1 | acetolactate synthase large subunit | - |
| HWQ15_RS08350 | 1761812..1762099 | + | 288 | WP_015570113.1 | acetolactate synthase small subunit | - |
| HWQ15_RS08355 | 1762225..1762818 | + | 594 | WP_022646555.1 | transcriptional regulator UhpA | - |
| HWQ15_RS08360 | 1762815..1764320 | + | 1506 | WP_063148987.1 | signal transduction histidine-protein kinase/phosphatase UhpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12441.55 Da Isoelectric Point: 10.1989
>T162653 WP_022646552.1 NZ_CP056118:1759038-1759352 [Enterobacter sp. DSM 30060]
MHLISMKAILDAVSQFPQYREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK
MHLISMKAILDAVSQFPQYREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK
Download Length: 315 bp
>T162653 NZ_CP071936:c79796-79032 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAGAGATAAGAAGCTAGAAGAAATGATTGTATTGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAAAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAACAACAAACGCAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGCTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGAAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATTTGATGGTTACAATTCTATTTGTGATTGGTTTTTGC
GGAGAATTGCATATAATACAAAGATTAGATTCTAAATATTTTTAA
ATGGAAACTAAAGAAGAAGATAGAGATAAGAAGCTAGAAGAAATGATTGTATTGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAAAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAACAACAAACGCAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGCTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGAAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATTTGATGGTTACAATTCTATTTGTGATTGGTTTTTGC
GGAGAATTGCATATAATACAAAGATTAGATTCTAAATATTTTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15480.10 Da Isoelectric Point: 5.6761
>AT162653 WP_022646553.1 NZ_CP056118:1759349-1759768 [Enterobacter sp. DSM 30060]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE
Download Length: 420 bp
>AT162653 NZ_CP071936:c80223-79786 [Helicobacter pylori]
ATGGTCAATACTTTGGAGCTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTGGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACGAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATAAATATCGTAATTACGGTGCCAATCCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATTGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGACTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATGGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAACAAATGGAAACTAA
ATGGTCAATACTTTGGAGCTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTGGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACGAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATAAATATCGTAATTACGGTGCCAATCCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATTGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGACTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATGGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAACAAATGGAAACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|