Detailed information of TA system TA162455

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 992724..992970
• Replicon: chromosome
• Accession: NZ_CP055675
• Organism: Escherichia fergusonii strain RHB28-C13

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVY52_RS04755
• Protein ID: WP_000956458.1
• Coordinates: 992818..992970 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	992724..992776 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY52_RS04740	988232..990031	+	1800	WP_181203169.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVY52_RS04745	990031..991743	+	1713	WP_115738177.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVY52_RS04750	991817..992551	+	735	WP_181203170.1	phosphoadenosine phosphosulfate reductase	-
-	992724..992776	-	53	-	-	Antitoxin
HVY52_RS04755	992818..992970	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVY52_RS04760	993206..995863	+	2658	WP_002431960.1	CRISPR-associated helicase/endonuclease Cas3	-
HVY52_RS04765	995961..997523	+	1563	WP_181203171.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T162455 WP_000956458.1 NZ_CP055675:992818-992970 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T162455 NZ_CP071796:1734022-1734429 [Ottowia testudinis]
ATGCTGCGCTACATGCTGGATACGAACATCGTCATCTACGTGATGAAGAGACGGCCTTTGGCGGCGCTGGAGGTGTTCAA
CCGCCATGCCGGGGCCATGTGCATCAGCAGCATCACGCTCTCAGAGCTGTGCCACGGTGCAGAAAAAAGCGAACGCCGCG
AACACAGCTTGCGCCATGTGGAGAGCTTTGTTTCGCGCCTGGAAGTGTTGCCCTACGGTGCCAAGGCAGCCATGCACTAC
GGCAGCATCCGCGCCATGCTGGAGCGGCAGGGCCAAATCATTGGCGAGAACGATCTGCACATCGCCGCCCATGCGCGCAG
CGAAGGCTTGACCCTGGTGAGCAACAACCTGCGCGAGTTCGAGCGCGTGCCTGGGCTGTTGCTGGAAAACTGGGTGGGGC
AGGGGTGA

Antitoxin

Nucleotide

• Length: 53 bp

>AT162455 NZ_CP055675:c992776-992724 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin