Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 18011..18558 Replicon plasmid pRHB41-C23_3
Accession NZ_CP055601
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag HV014_RS22630 Protein ID WP_000970007.1
Coordinates 18277..18558 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HV014_RS22625 Protein ID WP_000079941.1
Coordinates 18011..18280 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS22595 14247..14660 - 414 Protein_12 IS91 family transposase -
HV014_RS22600 14641..14913 - 273 WP_000019163.1 hypothetical protein -
HV014_RS22605 15128..15943 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
HV014_RS22610 16030..16272 + 243 Protein_15 phosphoglucosamine mutase -
HV014_RS22615 16226..16477 - 252 WP_001445143.1 hypothetical protein -
HV014_RS22620 16508..17644 - 1137 WP_023140202.1 IS91 family transposase -
HV014_RS22625 18011..18280 + 270 WP_000079941.1 hypothetical protein Antitoxin
HV014_RS22630 18277..18558 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV014_RS22635 18598..19446 + 849 WP_021265674.1 3'-5' exonuclease -
HV014_RS22640 19563..20036 + 474 WP_001334658.1 hypothetical protein -
HV014_RS22645 20513..20779 - 267 WP_000955263.1 hypothetical protein -
HV014_RS22650 20779..21273 - 495 WP_001459505.1 hypothetical protein -
HV014_RS22655 21329..21931 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA1 / blaTEM-1B / sul2 - 1..112380 112380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T162445 WP_000970007.1 NZ_CP055601:18277-18558 [Escherichia fergusonii]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T162445 NZ_CP071785:4596927-4597229 [Marinobacter sp. CA1]
ATGGCTGAAGTAATCTGGACAGAGCCCGCCCTTCAAGAACTGGATGCCATCGCTGAGTATATTGCTCTAGACAATCCTGC
TGCCGCACGCGATCTGGTCCAACAGGTTTTCGATAAGACCGAGCGTTTGGAAAACTTTCCTCAATCCGGGCGGATTCCTC
CCGAACTCCCCAATTCGGTATACAGAGAGGTCGTGGTTCAGCCGTGTCGTATTTTCTATCGTGAGGACGAGAGGCGGGTT
CTCATCCTCTATGTCATGCGAGAGGAGCGGCAGCTTCGTGCGTACATGCTTGGAAGCAGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT162445 WP_000079941.1 NZ_CP055601:18011-18280 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT162445 NZ_CP071785:4596682-4596939 [Marinobacter sp. CA1]
ATGAAAGTTGAGCTTGTTACAAACCTGAAGCGTCAAGCTACAAAAATCCTGGCAGACCTGCATCTGACCAAAGAGCCGGT
ACTGATCACTGAACATGGCCAGCCATCCGCTTATCTTGTTGATGTGCAGGATTACGAGTTCATGCAGCGCCGACTTGAGC
TGCTTGAGGGGCTCTCACGGGGAGAGCGAGCTGTACTAGAGGGAAGAATGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References