Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 50254..50855 Replicon plasmid pRHB41-C23_2
Accession NZ_CP055600
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name doc Uniprot ID F0JYA5
Locus tag HV014_RS22215 Protein ID WP_001216044.1
Coordinates 50254..50634 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag HV014_RS22220 Protein ID WP_001190712.1
Coordinates 50634..50855 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS22190 45694..47178 - 1485 WP_181199420.1 terminase -
HV014_RS22195 47178..48371 - 1194 WP_181199421.1 terminase -
HV014_RS22200 48458..48910 - 453 WP_181199422.1 Late promoter-activating protein -
HV014_RS22205 48999..50042 - 1044 WP_181199423.1 DUF968 domain-containing protein -
HV014_RS22210 50070..50249 - 180 WP_000113019.1 hypothetical protein -
HV014_RS22215 50254..50634 - 381 WP_001216044.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV014_RS22220 50634..50855 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV014_RS22225 51241..52221 - 981 WP_181199424.1 IS5 family transposase -
HV014_RS22230 52484..53872 + 1389 WP_001207923.1 nitrate/nitrite transporter NarU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(3'')-Ia / qacE / sul1 - 1..113051 113051
- flank IS/Tn - - 51241..52221 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13544.28 Da        Isoelectric Point: 5.6343

>T162444 WP_001216044.1 NZ_CP055600:c50634-50254 [Escherichia fergusonii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVAATLRRLYGSAE

Download         Length: 381 bp

>T162444 NZ_CP071785:c3290015-3289758 [Marinobacter sp. CA1]
ATGCACAAACTGACCTACAAGAAGTCGGCGCTGAAGGCGCTTCGAAAGATGCCGCGCCCGCAGGCGCAGAAGTTGCAGTG
TGAGCTGAGTGTTATTGCGAAAGACCCGTACGCATACAGCGGCGACTGGAAGCCCTTGAAAGGGGAGCCCTATTGGCGGT
TAAGGCAAGGGGGTTACCGGGCCGTCTGCAGTATTGATGACGGGGAGTTGTTAGTGCTGGTGCTTAAGGTCGGGCCAAGG
GGAGATGTTTACAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT162444 WP_001190712.1 NZ_CP055600:c50855-50634 [Escherichia fergusonii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT162444 NZ_CP071785:c3290417-3290112 [Marinobacter sp. CA1]
ATGCAGATAAAAACTAAGAGTGGCCGCGTGATTCAGCTGCCGACCGACGAGGAAGACGCCGAGATCAATGCCGGCATTGC
CGCCGATCCGGACACCTACGAGCTGTCAGACGAAGACTTCAAGCGCCTGCGGCCGATGGGGCGGCCCAAGGCTGAGGTAA
CCAAGGAGCGGATCACCATTCGGCTATCGCCGGATGTGGTGGAAGCCTTCCGGGCGACCGGCAAGGGCTGGCAGTCTCGA
ATGGATAAGGCGCTTCGTGAGTACGTGCAAGAGCACAGCCAGTCGGATATTGAGCGGCTTGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Y6HMN5

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References