Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4061122..4061801 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV014_RS19705 Protein ID WP_181198810.1
Coordinates 4061122..4061424 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV014_RS19710 Protein ID WP_000806441.1
Coordinates 4061460..4061801 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS19680 4056498..4058150 + 1653 WP_160193899.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HV014_RS19685 4058188..4058691 - 504 WP_000667001.1 hypothetical protein -
HV014_RS19690 4058688..4059488 - 801 WP_181198808.1 hypothetical protein -
HV014_RS19695 4059512..4059991 - 480 WP_181198809.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HV014_RS19700 4060195..4060989 - 795 WP_046081753.1 TraB/GumN family protein -
HV014_RS19705 4061122..4061424 + 303 WP_181198810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV014_RS19710 4061460..4061801 + 342 WP_000806441.1 HigA family addiction module antidote protein Antitoxin
HV014_RS19715 4061915..4064419 - 2505 WP_181198811.1 copper-exporting P-type ATPase CopA -
HV014_RS19720 4064726..4066015 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11753.34 Da        Isoelectric Point: 10.3339

>T162443 WP_181198810.1 NZ_CP055599:4061122-4061424 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAAELYLDPHNY

Download         Length: 303 bp

>T162443 NZ_CP071785:c3290015-3289758 [Marinobacter sp. CA1]
ATGCACAAACTGACCTACAAGAAGTCGGCGCTGAAGGCGCTTCGAAAGATGCCGCGCCCGCAGGCGCAGAAGTTGCAGTG
TGAGCTGAGTGTTATTGCGAAAGACCCGTACGCATACAGCGGCGACTGGAAGCCCTTGAAAGGGGAGCCCTATTGGCGGT
TAAGGCAAGGGGGTTACCGGGCCGTCTGCAGTATTGATGACGGGGAGTTGTTAGTGCTGGTGCTTAAGGTCGGGCCAAGG
GGAGATGTTTACAAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT162443 WP_000806441.1 NZ_CP055599:4061460-4061801 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp

>AT162443 NZ_CP071785:c3289761-3289384 [Marinobacter sp. CA1]
ATGAGCGCGCAAATCATTGAGCGAGAGGGCAAGCCGGAATATGCCGTGCTGCCTTACAGCGAATACCTGGAATTGCTCGC
GCTGGCGGAGGAAGTGAAGGATGCCGCGGATGCCAGGCAGGCTATGAGCGAGCTGAAGAATGGTGAGGATGAGGTGGTGC
CCGCCGTGGTCGCTGATCGGCTGATCGCCGGTGACGAGCATCCGCTGAAGGTTTGGCGGGAGTATCGCGGCTTGACCCAG
GAAGCCTTGGGTGCCGCCGCTGGTGTCGGGAAGTCCTACATCAGCCAGATTGAGGGCGCTGGTAAAACCGCTTCCACCAA
GGTTCTGAAAGCCCTGGCGCAAGCGCTGTCTGTGGATGTCGACGATCTTATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References