Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3587362..3587912 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HV014_RS17445 Protein ID WP_001160963.1
Coordinates 3587598..3587912 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HV014_RS17440 Protein ID WP_000125566.1
Coordinates 3587362..3587595 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS17415 3582434..3582721 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HV014_RS17420 3582780..3584111 + 1332 WP_181198739.1 MFS transporter -
HV014_RS17425 3584219..3584749 + 531 WP_000600701.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HV014_RS17430 3584742..3586604 + 1863 WP_104919956.1 glutathione-regulated potassium-efflux system protein KefC -
HV014_RS17435 3586797..3587276 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HV014_RS17440 3587362..3587595 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HV014_RS17445 3587598..3587912 + 315 WP_001160963.1 CcdB family protein Toxin
HV014_RS17450 3587909..3588757 - 849 WP_000257179.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HV014_RS17455 3588764..3589141 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HV014_RS17460 3589144..3589965 - 822 WP_001065390.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HV014_RS17465 3589962..3590951 - 990 WP_046076786.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HV014_RS17470 3590951..3592237 - 1287 WP_181198740.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T162439 WP_001160963.1 NZ_CP055599:3587598-3587912 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T162439 NZ_CP071780:c3828040-3827687 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATATGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT162439 WP_000125566.1 NZ_CP055599:3587362-3587595 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT162439 NZ_CP071780:c3828298-3828041 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTATCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References