Detailed information of TA system TA162437

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3541787..3542045
• Replicon: chromosome
• Accession: NZ_CP055599
• Organism: Escherichia fergusonii strain RHB41-C23

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV014_RS17225
• Protein ID: WP_181198725.1
• Coordinates: 3541787..3541996 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3541988..3542045 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV014_RS17205	3536852..3537439	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HV014_RS17210	3537473..3538039	-	567	WP_000528529.1	acetate uptake transporter	-
HV014_RS17215	3538547..3540463	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV014_RS17220	3540552..3541682	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HV014_RS17225	3541787..3541996	-	210	WP_181198725.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3541988..3542045	+	58	-	-	Antitoxin
HV014_RS17230	3542480..3543646	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HV014_RS17235	3543714..3544613	+	900	WP_000019049.1	transcriptional activator NhaR	-
HV014_RS17240	3544709..3544972	-	264	WP_001274021.1	30S ribosomal protein S20	-
HV014_RS17245	3545075..3545293	+	219	WP_181198726.1	DUF2575 domain-containing protein	-
HV014_RS17250	3545301..3546242	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T162437 WP_181198725.1 NZ_CP055599:c3541996-3541787 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAIVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T162437 NZ_CP071780:3521921-3522307 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT162437 NZ_CP055599:3541988-3542045 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin