Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1076705..1077207 | Replicon | chromosome |
| Accession | NZ_CP055219 | ||
| Organism | Shigella flexneri strain STEFF_12 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HUZ41_RS05705 | Protein ID | WP_000767829.1 |
| Coordinates | 1076705..1076959 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUZ41_RS05710 | Protein ID | WP_001259255.1 |
| Coordinates | 1076956..1077207 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ41_RS05675 (1071720) | 1071720..1071947 | - | 228 | WP_000985270.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| HUZ41_RS05680 (1071961) | 1071961..1073019 | - | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUZ41_RS05685 (1073198) | 1073198..1074556 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUZ41_RS05690 (1074546) | 1074546..1074608 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUZ41_RS05695 (1074823) | 1074823..1075752 | - | 930 | WP_000803370.1 | LysR substrate-binding domain-containing protein | - |
| HUZ41_RS05700 (1075798) | 1075798..1076622 | - | 825 | WP_024238800.1 | SDR family oxidoreductase | - |
| HUZ41_RS05705 (1076705) | 1076705..1076959 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUZ41_RS05710 (1076956) | 1076956..1077207 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUZ41_RS05715 (1077490) | 1077490..1077540 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUZ41_RS05720 (1077686) | 1077686..1078585 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HUZ41_RS05725 (1078591) | 1078591..1079895 | + | 1305 | WP_001593467.1 | histidinol dehydrogenase | - |
| HUZ41_RS05730 (1079892) | 1079892..1080962 | + | 1071 | WP_000108967.1 | histidinol-phosphate transaminase | - |
| HUZ41_RS05735 (1080962) | 1080962..1082029 | + | 1068 | WP_239637082.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T162001 WP_000767829.1 NZ_CP055219:c1076959-1076705 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T162001 NZ_CP071457:241734-242156 [Rhizobium lentis]
GTGAAGCTGCTGCTGGACACCAATGTTCTGTCTGAGGTGACGAAGCCGAACCCTGATGCGCGCGTCCTAGAATGGCTGGA
TGGGCTCGACGAGGATCGCACCTTCATCAGCATCGTGTCGGTCGCGGAGATCCGTCGCGGCGTTGCCCTGATGGACAAGG
GACGCAAACGCGATGCACTGGCCGAATGGCTTGTCCAAGACCTGACGCAACGCTTCGAGCGCCGCATCATTGCGGTGGAC
GAACCGGTTGCCTTGGCCTGGGGAGACCTCATGGGCCATGCAAAGCGGAGCGGCCGCGGGCTGTCCTCGATGGATGGCCT
GATCGCGGCCACCGCGATTGCTCATGATCTCAGCCTCGCGACGCGTAACACGAGGGATTTCGAGGGCTTTGGGATCGAGC
TGATCGATCCCTGGATTGGATGA
GTGAAGCTGCTGCTGGACACCAATGTTCTGTCTGAGGTGACGAAGCCGAACCCTGATGCGCGCGTCCTAGAATGGCTGGA
TGGGCTCGACGAGGATCGCACCTTCATCAGCATCGTGTCGGTCGCGGAGATCCGTCGCGGCGTTGCCCTGATGGACAAGG
GACGCAAACGCGATGCACTGGCCGAATGGCTTGTCCAAGACCTGACGCAACGCTTCGAGCGCCGCATCATTGCGGTGGAC
GAACCGGTTGCCTTGGCCTGGGGAGACCTCATGGGCCATGCAAAGCGGAGCGGCCGCGGGCTGTCCTCGATGGATGGCCT
GATCGCGGCCACCGCGATTGCTCATGATCTCAGCCTCGCGACGCGTAACACGAGGGATTTCGAGGGCTTTGGGATCGAGC
TGATCGATCCCTGGATTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT162001 WP_001259255.1 NZ_CP055219:c1077207-1076956 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT162001 NZ_CP071457:241471-241737 [Rhizobium lentis]
ATGCAGACATCACGGCAAGGCGATGAAAGCTGGACCGTTGCCAGTGCAAAGGCGAAGCTTTCCGAGGTGATCGAACGCGC
GCAATCCGCGCCACAGACAATCACACGCAACGGCAAGCCCAGCGTCGTCGTCGTCTCCGCTGAGGAATGGCAGCGGAAGA
CGGCGCGGAAGGGGACGCTCGCCGAATTTCTGATGGAATCGCCGCTCCGCGGCGCCGATCTGGATCTTGAGCGTCAACGC
GACGAACCGTCTGATCCGACGCTGTGA
ATGCAGACATCACGGCAAGGCGATGAAAGCTGGACCGTTGCCAGTGCAAAGGCGAAGCTTTCCGAGGTGATCGAACGCGC
GCAATCCGCGCCACAGACAATCACACGCAACGGCAAGCCCAGCGTCGTCGTCGTCTCCGCTGAGGAATGGCAGCGGAAGA
CGGCGCGGAAGGGGACGCTCGCCGAATTTCTGATGGAATCGCCGCTCCGCGGCGCCGATCTGGATCTTGAGCGTCAACGC
GACGAACCGTCTGATCCGACGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|