Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3935419..3936217 | Replicon | chromosome |
| Accession | NZ_CP055113 | ||
| Organism | Shigella flexneri strain SWHIN_101 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | HUZ81_RS19050 | Protein ID | WP_000854735.1 |
| Coordinates | 3935419..3935796 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A067H947 |
| Locus tag | HUZ81_RS19055 | Protein ID | WP_001285415.1 |
| Coordinates | 3935843..3936217 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ81_RS19020 (3931565) | 3931565..3932698 | + | 1134 | Protein_3714 | Accessory colonization factor AcfD | - |
| HUZ81_RS19025 (3933116) | 3933116..3933442 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HUZ81_RS19030 (3933439) | 3933439..3933702 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HUZ81_RS19035 (3933774) | 3933774..3934640 | - | 867 | WP_001280433.1 | DUF4942 domain-containing protein | - |
| HUZ81_RS19040 (3934725) | 3934725..3934922 | - | 198 | WP_000839291.1 | DUF957 domain-containing protein | - |
| HUZ81_RS19045 (3934934) | 3934934..3935422 | - | 489 | WP_000761677.1 | DUF5983 family protein | - |
| HUZ81_RS19050 (3935419) | 3935419..3935796 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| HUZ81_RS19055 (3935843) | 3935843..3936217 | - | 375 | WP_001285415.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ81_RS19060 (3936297) | 3936297..3936518 | - | 222 | WP_000692309.1 | DUF987 domain-containing protein | - |
| HUZ81_RS19065 (3936581) | 3936581..3937057 | - | 477 | WP_001366855.1 | RadC family protein | - |
| HUZ81_RS19070 (3937073) | 3937073..3937552 | - | 480 | WP_000844100.1 | antirestriction protein | - |
| HUZ81_RS19075 (3937634) | 3937634..3938452 | - | 819 | WP_001175148.1 | DUF932 domain-containing protein | - |
| HUZ81_RS19080 (3938542) | 3938542..3938775 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| HUZ81_RS19085 (3938781) | 3938781..3939458 | - | 678 | WP_001097302.1 | hypothetical protein | - |
| HUZ81_RS19090 (3939606) | 3939606..3940286 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3933116..3997448 | 64332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T161599 WP_000854735.1 NZ_CP055113:c3935796-3935419 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T161599 NZ_CP071228:1601802-1602110 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13663.32 Da Isoelectric Point: 5.8640
>AT161599 WP_001285415.1 NZ_CP055113:c3936217-3935843 [Shigella flexneri]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT161599 NZ_CP071228:1601563-1601799 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCTGTATTGACGGACGCATTGAGCGTCCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCTGTATTGACGGACGCATTGAGCGTCCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067H947 |