Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2689102..2689900 Replicon chromosome
Accession NZ_CP055113
Organism Shigella flexneri strain SWHIN_101

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HUZ81_RS13135 Protein ID WP_000854735.1
Coordinates 2689523..2689900 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HUZ81_RS13130 Protein ID WP_032153712.1
Coordinates 2689102..2689476 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ81_RS13095 (2684835) 2684835..2685719 + 885 WP_024166630.1 50S ribosome-binding GTPase -
HUZ81_RS13100 (2685838) 2685838..2686515 + 678 WP_023155728.1 hypothetical protein -
HUZ81_RS13105 (2686545) 2686545..2686754 + 210 WP_023155727.1 DUF905 family protein -
HUZ81_RS13110 (2686845) 2686845..2687663 + 819 WP_001234693.1 DUF932 domain-containing protein -
HUZ81_RS13115 (2687755) 2687755..2688240 + 486 WP_032153711.1 antirestriction protein -
HUZ81_RS13120 (2688256) 2688256..2688732 + 477 WP_001186715.1 RadC family protein -
HUZ81_RS13125 (2688801) 2688801..2689022 + 222 WP_000692345.1 DUF987 domain-containing protein -
HUZ81_RS13130 (2689102) 2689102..2689476 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HUZ81_RS13135 (2689523) 2689523..2689900 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HUZ81_RS13140 (2689897) 2689897..2690388 + 492 WP_023155722.1 DUF5983 family protein -
HUZ81_RS13145 (2690400) 2690400..2690597 + 198 WP_000839265.1 DUF957 domain-containing protein -
HUZ81_RS13150 (2690682) 2690682..2691548 + 867 WP_032153714.1 DUF4942 domain-containing protein -
HUZ81_RS13155 (2691620) 2691620..2691883 + 264 WP_215744564.1 type II toxin-antitoxin system ParD family antitoxin -
HUZ81_RS13160 (2691880) 2691880..2692206 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUZ81_RS13165 (2693089) 2693089..2694626 + 1538 Protein_2583 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCTX-M-14 / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 papB / papI 2621518..2702439 80921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T161594 WP_000854735.1 NZ_CP055113:2689523-2689900 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T161594 NZ_CP071226:c4164460-4164038 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT161594 WP_032153712.1 NZ_CP055113:2689102-2689476 [Shigella flexneri]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT161594 NZ_CP071226:c4164707-4164441 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References