161591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1807383..1808220 Replicon chromosome
Accession NZ_CP055113
Organism Shigella flexneri strain SWHIN_101

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag HUZ81_RS08800 Protein ID WP_000227784.1
Coordinates 1807678..1808220 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag HUZ81_RS08795 Protein ID WP_001297137.1
Coordinates 1807383..1807694 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ81_RS08770 (1802403) 1802403..1803350 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
HUZ81_RS08775 (1803372) 1803372..1805363 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HUZ81_RS08780 (1805353) 1805353..1805967 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HUZ81_RS08785 (1805967) 1805967..1806296 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HUZ81_RS08790 (1806308) 1806308..1807198 + 891 WP_000971336.1 heme o synthase -
HUZ81_RS08795 (1807383) 1807383..1807694 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
HUZ81_RS08800 (1807678) 1807678..1808220 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
HUZ81_RS08805 (1808276) 1808276..1809211 - 936 WP_001365761.1 tetratricopeptide repeat protein -
HUZ81_RS08810 (1809619) 1809619..1810983 + 1365 WP_001000974.1 MFS transporter -
HUZ81_RS08815 (1811111) 1811111..1811602 - 492 WP_001138904.1 nucleotide binding protein YajQ -
HUZ81_RS08820 (1811770) 1811770..1812681 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T161591 WP_000227784.1 NZ_CP055113:1807678-1808220 [Shigella flexneri]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T161591 NZ_CP071226:2039720-2039816 [Serratia marcescens subsp. marcescens ATCC 13880]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT161591 WP_001297137.1 NZ_CP055113:1807383-1807694 [Shigella flexneri]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT161591 NZ_CP071226:c2039816-2039676 [Serratia marcescens subsp. marcescens ATCC 13880]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References