Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2836499..2837334 | Replicon | chromosome |
| Accession | NZ_CP055070 | ||
| Organism | Shigella flexneri strain SWHIN_97 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6H2GFM1 |
| Locus tag | HUZ91_RS14105 | Protein ID | WP_065304416.1 |
| Coordinates | 2836499..2836876 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A6H2GGB7 |
| Locus tag | HUZ91_RS14110 | Protein ID | WP_001285390.1 |
| Coordinates | 2836966..2837334 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ91_RS14065 (2831769) | 2831769..2832260 | - | 492 | WP_001300785.1 | DUF1097 domain-containing protein | - |
| HUZ91_RS14070 (2832362) | 2832362..2832916 | - | 555 | WP_033554356.1 | molecular chaperone YcdY | - |
| HUZ91_RS14075 (2832940) | 2832940..2833677 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| HUZ91_RS14080 (2833732) | 2833732..2834670 | - | 939 | WP_000351315.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| HUZ91_RS14090 (2835141) | 2835141..2835983 | - | 843 | WP_065304417.1 | DUF4942 domain-containing protein | - |
| HUZ91_RS14095 (2836080) | 2836080..2836277 | - | 198 | WP_086598277.1 | DUF957 domain-containing protein | - |
| HUZ91_RS14100 (2836353) | 2836353..2836502 | - | 150 | Protein_2770 | DUF5983 family protein | - |
| HUZ91_RS14105 (2836499) | 2836499..2836876 | - | 378 | WP_065304416.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| HUZ91_RS14110 (2836966) | 2836966..2837334 | - | 369 | WP_001285390.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ91_RS14115 (2837384) | 2837384..2838028 | - | 645 | WP_065304415.1 | antitoxin of toxin-antitoxin stability system | - |
| HUZ91_RS14120 (2838043) | 2838043..2838264 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| HUZ91_RS14125 (2838333) | 2838333..2838809 | - | 477 | WP_001186747.1 | RadC family protein | - |
| HUZ91_RS14130 (2838824) | 2838824..2839309 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| HUZ91_RS14135 (2839400) | 2839400..2840221 | - | 822 | WP_106668205.1 | DUF932 domain-containing protein | - |
| HUZ91_RS14140 (2840442) | 2840442..2840852 | - | 411 | WP_000846713.1 | hypothetical protein | - |
| HUZ91_RS14145 (2840868) | 2840868..2841545 | - | 678 | WP_059239983.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgB / csgD / csgE / csgF / csgG | 2828150..2867482 | 39332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14060.06 Da Isoelectric Point: 7.8522
>T161355 WP_065304416.1 NZ_CP055070:c2836876-2836499 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
Download Length: 378 bp
>T161355 NZ_CP071128:3826544-3826954 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTAGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTAGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.52 Da Isoelectric Point: 5.9618
>AT161355 WP_001285390.1 NZ_CP055070:c2837334-2836966 [Shigella flexneri]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT161355 NZ_CP071128:3826269-3826547 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCAGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCAGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GFM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GGB7 |