Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4720617..4721133 Replicon chromosome
Accession NZ_CP055061
Organism Klebsiella pneumoniae strain SWHE3

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HUZ66_RS22925 Protein ID WP_004178374.1
Coordinates 4720617..4720901 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ66_RS22930 Protein ID WP_002886901.1
Coordinates 4720891..4721133 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ66_RS22900 (HUZ66_22855) 4716034..4716297 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
HUZ66_RS22905 (HUZ66_22860) 4716427..4716600 + 174 WP_019725541.1 hypothetical protein -
HUZ66_RS22910 (HUZ66_22865) 4716603..4717346 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ66_RS22915 (HUZ66_22870) 4717703..4719841 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ66_RS22920 (HUZ66_22875) 4720149..4720613 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ66_RS22925 (HUZ66_22880) 4720617..4720901 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ66_RS22930 (HUZ66_22885) 4720891..4721133 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ66_RS22935 (HUZ66_22890) 4721211..4723121 - 1911 WP_019725539.1 PRD domain-containing protein -
HUZ66_RS22940 (HUZ66_22895) 4723144..4724298 - 1155 WP_004178372.1 lactonase family protein -
HUZ66_RS22945 (HUZ66_22900) 4724365..4725105 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T161314 WP_004178374.1 NZ_CP055061:c4720901-4720617 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T161314 NZ_CP071128:841227-841655 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGACGCTCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT161314 WP_002886901.1 NZ_CP055061:c4721133-4720891 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT161314 NZ_CP071128:840946-841203 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References