Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3944671..3945290 Replicon chromosome
Accession NZ_CP055033
Organism Klebsiella pneumoniae strain SWHEFF_62

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ73_RS19485 Protein ID WP_002892050.1
Coordinates 3945072..3945290 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUZ73_RS19480 Protein ID WP_002892066.1
Coordinates 3944671..3945045 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ73_RS19470 (3939823) 3939823..3941016 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ73_RS19475 (3941039) 3941039..3944185 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HUZ73_RS19480 (3944671) 3944671..3945045 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUZ73_RS19485 (3945072) 3945072..3945290 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ73_RS19490 (3945449) 3945449..3946015 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUZ73_RS19495 (3945987) 3945987..3946127 - 141 WP_004147370.1 hypothetical protein -
HUZ73_RS19500 (3946148) 3946148..3946618 + 471 WP_002892026.1 YlaC family protein -
HUZ73_RS19505 (3946593) 3946593..3948044 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
HUZ73_RS19510 (3948145) 3948145..3948843 + 699 WP_002892021.1 GNAT family protein -
HUZ73_RS19515 (3948840) 3948840..3948980 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUZ73_RS19520 (3948980) 3948980..3949243 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161128 WP_002892050.1 NZ_CP055033:3945072-3945290 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T161128 NZ_CP071062:1684163-1684420 [Dickeya solani]
ATGCCTGAGGTTGATAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTATGATGATGAGCGGCACTACTTGCCGCATGT
ACATGTCTGCTACGGCAACCATGAGCTGATCATCAGTATTCGTACTGGAACCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGATGGCGCTTGCGCATATCAGGGCCCATCGGGAACAACTGCTGAGTATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCAGGAAAATTGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT161128 WP_002892066.1 NZ_CP055033:3944671-3945045 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT161128 NZ_CP071062:1684428-1684943 [Dickeya solani]
ATGCATAAAATCGTGGAAGTTGACGTTATTGGTGATTTTTCGTTGCGCCTGACCTATGACGATGGTCTGGTTTGCGACAT
TAATCTTTATCAATATGCGTCCAGCCCAGTATTTTCGGACGTCAGCCTATTTATCAAGTTTGGGTTGTTGCCGGATGGCG
CGTTGGAATGGCTGCCGGATATTAAGATTTCCGCGTCAGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAAAGGCACTTCGCCGATGTCATCTCGCGCGCCTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCAGCGTTGAAAATCGCGGTGGAAAAACATGGCAACAGCACCGTAGCCAAAGAGGCGGGGGCGAAAAGTCGCACCAGCT
TGTATAAGTCGCTGAATAAAAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAGTTGGAA
GAGTTGCAATTGGAAGATCTGCAATTGGAAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References