Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4807242..4807758 Replicon chromosome
Accession NZ_CP055005
Organism Klebsiella pneumoniae strain STIN_77

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUZ53_RS23555 Protein ID WP_002886902.1
Coordinates 4807242..4807526 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ53_RS23560 Protein ID WP_002886901.1
Coordinates 4807516..4807758 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ53_RS23530 (HUZ53_23490) 4802726..4802989 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
HUZ53_RS23535 (HUZ53_23495) 4803119..4803292 + 174 WP_002886906.1 hypothetical protein -
HUZ53_RS23540 (HUZ53_23500) 4803295..4804038 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ53_RS23545 (HUZ53_23505) 4804395..4806533 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ53_RS23550 (HUZ53_23510) 4806774..4807238 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ53_RS23555 (HUZ53_23515) 4807242..4807526 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ53_RS23560 (HUZ53_23520) 4807516..4807758 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ53_RS23565 (HUZ53_23525) 4807836..4809746 - 1911 WP_004152270.1 PRD domain-containing protein -
HUZ53_RS23570 (HUZ53_23530) 4809769..4810923 - 1155 WP_002886900.1 lactonase family protein -
HUZ53_RS23575 (HUZ53_23535) 4810989..4811729 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T160950 WP_002886902.1 NZ_CP055005:c4807526-4807242 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160950 NZ_CP070977:c1176924-1176508 [Burkholderia pyrrocinia]
GTGACCACGCTCTACATGCTCGATACGAACATTTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCGCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCAATTACCTATGCCGAAATGCGGTTCGGCGCGGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATCCGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCGGATCTCGCCGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATTGCGGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAATTCGGCCGTGTCGCCGGGTTGTCGTTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160950 WP_002886901.1 NZ_CP055005:c4807758-4807516 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160950 NZ_CP070977:c1177184-1176921 [Burkholderia pyrrocinia]
ATGCGCACTGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGATACGCTGCTGCTGCGGCCGGTGCGTCCCACGTGGCTTTCGTTCGCGAACGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGTTTCGACCTGTCCGGCGATGCCGGC
TCGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References