Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842053..842710 Replicon chromosome
Accession NZ_CP055003
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ54_RS04225 Protein ID WP_002916310.1
Coordinates 842300..842710 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ54_RS04220 Protein ID WP_002916312.1
Coordinates 842053..842319 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS04195 (HUZ54_04190) 837261..838694 - 1434 WP_239619662.1 6-phospho-beta-glucosidase -
HUZ54_RS04200 (HUZ54_04195) 838813..839541 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ54_RS04205 (HUZ54_04200) 839591..839902 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ54_RS04210 (HUZ54_04205) 840066..840725 + 660 WP_002916317.1 hemolysin III family protein -
HUZ54_RS04215 (HUZ54_04210) 840824..841807 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
HUZ54_RS04220 (HUZ54_04215) 842053..842319 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ54_RS04225 (HUZ54_04220) 842300..842710 + 411 WP_002916310.1 protein YgfX Toxin
HUZ54_RS04230 (HUZ54_04225) 842717..843238 - 522 WP_004144730.1 flavodoxin FldB -
HUZ54_RS04235 (HUZ54_04230) 843339..844235 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ54_RS04240 (HUZ54_04235) 844258..844971 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ54_RS04245 (HUZ54_04240) 844977..846710 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T160917 WP_002916310.1 NZ_CP055003:842300-842710 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T160917 NZ_CP070964:781252-781419 [Staphylococcus sp. SB1-57]
GTGCAACAAAAAATTGTTTATACAGCTGGTATAGAAACACAAGAACAATCTGAATCTGTAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGAAATCGATATCAATACTGGAAACATTTCAATAGAATTTGAAACACCTGCGAATTTAAATA
GTATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT160917 WP_002916312.1 NZ_CP055003:842053-842319 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160917 NZ_CP070964:780948-781241 [Staphylococcus sp. SB1-57]
GTGACAGAACAAGATCATGCGCATCACTCTGAACAAAGTAAAGCAAATTTAAAATCGAGATTAAACCGTATTGAAGGTCA
AGTGAGAGCTATTAATCGAATGATAGAAGAAGATGTATATTGCGATGATGTGTTAACTCAAATCAGAGCTACACGTTCTG
CATTAAATAGCGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATTGCAGAAAAAGTTAATCAAGGACATCAA
GAAGAGGCAATGGAAGAGCTACTCGTTACTTTTCAAAAACTTATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References